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首页> 外文期刊>Addiction biology >Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
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Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.

机译：3,4-亚甲基二氧基甲基苯丙胺（摇头丸）在抑郁症大鼠模型中的作用增加。

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3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is associated with increases in core body temperature (T(C)) and depressive mood states in users. Flinders Sensitive Line (FSL) rats represent a rat model of depression originally bred from Sprague-Dawley (SD) rats. They are more sensitive to both muscarinic and serotonergic agonists and have altered thermoregulatory responses to various drugs. To examine the link between MDMA and depression, eight FSL and eight SD rats were administered saline and 5 and 7.5 mg/kg MDMA. Immediately following administration, rats were confined to an area with an ambient temperature (T(A)) of 30 +/- 1 degrees C for 30 minutes before being allowed access to a thermal gradient for four hours. The brains were removed one week after final dose of MDMA and concentrations of serotonin and dopamine were measured. Treatment with MDMA at both doses led to a higher T(C) in the FSL rats than the SD rats at high T(A) (P < 0.01). Fatalities due to hyperthermia occurred in the FSL rats after both doses, whereas all but one of the SD rats recovered well. Heart rate was also much higher after MDMA in the FSL rats throughout the experiments. The FSL rats showed significant decreases in all transmitters measured (P < 0.05). These differences between strains were not accounted for by altered blood or brain concentrations of MDMA. The results indicate that the FSL rats may be more susceptible to developing MDMA-induced hyperthermia and possible damage to the brain. These findings may be of importance to human users of MDMA who also have depression.
机译：3,4-亚甲二氧基甲基苯丙胺（摇头丸，摇头丸）与使用者核心体温（T（C））升高和情绪低落有关。 Flinders Sensitive Line（FSL）大鼠代表最初从Sprague-Dawley（SD）大鼠繁殖的抑郁症大鼠模型。它们对毒蕈碱和血清素激动剂都更敏感，并且改变了对各种药物的温度调节反应。为了检查MDMA与抑郁症之间的联系，给了8只FSL和8只SD大鼠施用了盐水以及5和7.5mg / kg的MDMA。给药后立即将大鼠限制在环境温度（T（A））为30 +/- 1摄氏度的区域中30分钟，然后允许其进入热梯度达四个小时。最终剂量的MDMA一周后取出大脑，并测量5-羟色胺和多巴胺的浓度。两种剂量的MDMA处理均导致FSL大鼠的T（C）高于高T（A）的SD大鼠（P <0.01）。两次给药后，FSL大鼠均因体温过高而致死，而除一只SD大鼠外，其余全部恢复良好。在整个实验中，FSL大鼠中的MDMA后心率也高得多。 FSL大鼠在所有测得的递质中均显示出显着下降（P <0.05）。血液或大脑中MDMA浓度的变化不能解释菌株之间的这些差异。结果表明，FSL大鼠可能更容易发生由MDMA引起的体温过高和对大脑的可能损害。这些发现对于患有抑郁症的MDMA人类使用者可能很重要。

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