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首页> 外文期刊>Addiction biology >Ghrelin system in alcohol-dependent subjects: Role of plasma ghrelin levels in alcohol drinking and craving
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Ghrelin system in alcohol-dependent subjects: Role of plasma ghrelin levels in alcohol drinking and craving

机译：Ghrelin系统在酒精依赖者中：血浆Ghrelin水平在饮酒和渴望中的作用

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Animal studies suggest that the gut-brain peptide ghrelin plays an important role in the neurobiology of alcohol dependence (AD). Human studies show an effect of alcohol on ghrelin levels and a correlation between ghrelin levels and alcohol craving in alcoholics. This investigation consisted of two studies. Study 1 was a 12-week study with alcohol-dependent subjects, where plasma ghrelin determinations were assessed four times (T0-T3) and related to alcohol intake and craving [Penn Alcohol Craving Score (PACS) and Obsessive Compulsive Drinking Scale (OCDS)]. Serum growth hormone levels and assessment of the nutritional/metabolic status were also performed. Study 2 was a pilot case-control study to assess ghrelin gene polymorphisms (Arg51Gln and Leu72Met) in alcohol-dependent individuals. Study 1 showed no significant differences in ghrelin levels in the whole sample, while there was a statistical difference for ghrelin between non-abstinent and abstinent subjects. Baseline ghrelin levels were significantly and positively correlated with the PACS score at T1 and with all craving scores both at T2 and T3 (PACS, OCDS, obsessive and compulsive OCDS subscores). In Study 2, although there was a higher frequency of the Leu72Met ghrelin gene polymorphism in alcohol-dependent individuals, the distribution between healthy controls and alcohol dependent individuals was not statistically significant. This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD.
机译：动物研究表明，脑肠肽Ghrelin在酒精依赖（AD）的神经生物学中起着重要作用。人体研究表明，酒精对生长激素释放肽水平有影响，且生长激素释放肽水平与酗酒者对酒精的渴望之间存在相关性。这项调查包括两项研究。研究1是一项为期12周的研究，研究对象为酒精依赖型受试者，其中四次（T0-T3）评估了血浆生长素释放肽的含量，且与饮酒和饮酒的渴望[Penn酒精渴望评分（PACS）和强迫性饮酒量表（OCDS） ]。还进行了血清生长激素水平和营养/代谢状态的评估。研究2是一项病例对照试验，目的是评估酒精依赖者的ghrelin基因多态性（Arg51Gln和Leu72Met）。研究1显示，整个样本中的生长激素释放肽水平没有显着差异，而在非戒断和戒断对象之间的生长激素释放肽有统计学差异。基线生长激素释放肽水平与T1时的PACS评分以及T2和T3时的所有渴望评分（PACS，OCDS，强迫和强迫性OCDS子评分）显着正相关。在研究2中，尽管在酒精依赖者中Leu72Met ghrelin基因多态性的频率更高，但健康对照与酒精依赖者之间的分布在统计学上并不显着。这项研究表明，生长素释放肽可能潜在地影响寻求酒精的行为，例如饮酒和渴望，这代表了AD的新的潜在神经药理学目标。

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