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A limited role for ghrelin in heroin self-administration and food deprivation-induced reinstatement of heroin seeking in rats

机译：生长激素释放肽在海洛因自我管理和食物缺乏引起的海洛因恢复过程中的作用有限

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摘要

Food deprivation (FD) or restriction augments the locomotor activating and reinforcing effects of drugs of abuse. It has been proposed that these effects might be mediated by FD-induced increase in plasma levels of ghrelin, a 28-amino acid orexigenic peptide demonstrated to functionally interact with the mesolimbic dopaminergic system. However, a role for ghrelin has been demonstrated only with psychostimulant drugs and alcohol associated behaviors. We therefore examined the role of ghrelin in ongoing heroin self-administration and FD-induced reinstatement of extinguished heroin seeking. As expected, infusions of ghrelin [0.0, 1.5 and 3.0 μg/rat, intracerebroventricular (i.c.v.)] produced increases in breakpoints on a progressive ratio schedule of heroin reinforcement. In contrast, central administration of a ghrelin receptor antagonist, [D-Lys-3]-GHRP-6 (0.0, or 20.0 μg/rat, i.c.v.) had no effect on ongoing heroin self-administration under a fixed-ratio 1 schedule, or on FD-induced reinstatement of heroin seeking. These results suggest that signals mediated through ghrelin receptors play a limited role in FD-induced augmentation of heroin reinforcement and reinstatement of extinguished heroin seeking.
机译：食物剥夺（FD）或限制会增强滥用药物的运动激活和增强作用。已经提出这些作用可能是由FD诱导的生长素释放肽血浆水平的升高所介导的，生长素释放肽是一种28氨基酸的致癌肽，被证明与中脑边缘多巴胺能系统发生功能性相互作用。但是，只有在使用精神刺激药和与酒精有关的行为中证明了生长素释放肽的作用。因此，我们研究了ghrelin在正在进行的海洛因自我管理和FD诱导的灭绝海洛因恢复过程中的作用。如所预期的，根据海洛因强化的逐步进行时间表，生长素释放肽[0.0、1.5和3.0μg/大鼠，脑室内（i.c.v.）]的输注产生的断点增加。相比之下，生长激素释放肽受体拮抗剂[D-Lys-3] -GHRP-6（0.0或20.0μg/大鼠，icv）的集中给药对固定比例1的海洛因自我给药没有影响，或通过FD诱导的海洛因恢复。这些结果表明，通过生长素释放肽受体介导的信号在FD诱导的海洛因增强的增强和灭绝的海洛因寻找的恢复中起有限的作用。

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