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Dopaminergic genes modulate response inhibition in alcohol abusing adults

机译：多巴胺能基因调节滥用酒精的成年人的反应抑制

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摘要

Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster-corrected P < 0.05, z = 1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster-corrected P < 0.05, z = 1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self-monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence.
机译：酒精使用障碍（AUD）的强迫症已归因于反应抑制的损害。由于基于行为研究，调节多巴胺（DA）的基因不仅与AUD风险有关，而且与冲动有关，因此我们着手研究与这些作用相关的潜在神经机制。在执行Go / NoGo任务时，我们收集了53名酗酒但健康的成年人的功能性磁共振成像图像。我们预测先前在文献中报道的与药物滥用相关的遗传变异，特别是DRD2 rs1799732和DRD4 VNTR，将调节潜在的反应抑制神经过程。我们的结果表明，在下额回（IFG）成功抑制过程中，DRD4 VNTR的神经反应不同（集群校正的P <0.05，z = 1.9）。同样，在成功抑制反应期间，DRD2 rs1799732组的前神经元和扣带回明显不同（集群校正的P <0.05，z = 1.9）。这些发现为DAergic基因在调节反应抑制和自我监控过程基础的区域中调节神经反应中的作用提供了进一步的证据。这些基因中的变异似乎会影响与冲动行为有关的过程，这可能会增加一个人酗酒和依赖的风险。

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