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首页> 外文期刊>Addiction biology >Co-sensitivity to the incentive properties of palatable food and cocaine in rats; Implications for co-morbid addictions
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Co-sensitivity to the incentive properties of palatable food and cocaine in rats; Implications for co-morbid addictions

机译：对可口食物和可卡因大鼠的刺激特性具有共同敏感性;对共病成瘾的影响

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Several lines of evidence suggest that there may be a shared vulnerability to acquire behaviors motivated by strong incentive stimuli. Non-food restricted male Sprague-Dawley rats (n = 78) underwent place conditioning with Oreos, and were subsequently tested on cocaine self-administration (SA) on fixed and progressive ratios, as well as extinction and reinstatement by cocaine primes and by consumption of Oreos. Although there was a group preference for the Oreo-paired compartment, at the individual level some rats (69%) displayed a preference and others did not. In cocaine SA, 'preference' rats achieved higher break points on a progressive ratio, and displayed greater responding during extinction and cocaine-induced reinstatement. Within the context of this study, Oreo-cocaine cross-reinstatement was not observed. In a control study, rats (n = 29) conditioned with a less palatable food (rice cakes) also displayed individual differences in place preference, but not on subsequent cocaine tests. These findings indicate that there is a relationship between incentive learning promoted by palatable foods and by cocaine. This supports the hypothesis that co-morbid food-drug addictions may result from a shared vulnerability to acquire behaviors motivated by strong incentives.
机译：有几条证据表明，在强烈的激励刺激下，习得行为可能存在一个共同的脆弱性。非食物受限的雄性Sprague-Dawley大鼠（n = 78）用奥利奥（Oreos）进行了场所调节，随后接受了可卡因自我给药（SA）的固定和渐进比例测试，并通过可卡因素和通过消耗进行了灭绝和恢复奥利奥岛。尽管对奥利奥配对室有一个群体的偏好，但在个体水平上，一些大鼠（69％）表现出偏好，而另一些则没有。在可卡因SA中，“偏爱”大鼠在渐进比率上获得了更高的断裂点，并且在灭绝和可卡因诱导的恢复过程中表现出更大的反应。在本研究的背景下，未观察到奥利奥可卡因交叉还原。在一项对照研究中，以不那么可口的食物（米饼）为食的大鼠（n = 29）在位置偏好上也表现出个体差异，但在随后的可卡因试验中却没有。这些发现表明，可口食品和可卡因促进的动机学习之间存在联系。这支持了这样的假说，即共病的食品和药物成瘾可能是由于共同的脆弱性而导致的，这些脆弱性是由于强烈的动机而导致的行为习得。

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