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首页> 外文期刊>Molecules >Biological Properties of Low-Toxic PLGA and PLGA/PHB Fibrous Nanocomposite Scaffolds for Osseous Tissue Regeneration. Evaluation of Potential Bioactivity
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Biological Properties of Low-Toxic PLGA and PLGA/PHB Fibrous Nanocomposite Scaffolds for Osseous Tissue Regeneration. Evaluation of Potential Bioactivity

机译：低毒性PLGA和PLGA / PHB纤维纳米复合支架的生物学性能，用于骨组织再生。 评估潜在的生物活性

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摘要

The aim of the study was to evaluate the biocompatibility and bioactivity of two new prototype implants for bone tissue regeneration made from biodegradable fibrous materials. The first is a newly developed poly(l-lactide-co-glycolide), (PLGA), and the second is a blend of PLGA with synthetic poly([R,S]-3-hydroxybutyrate) (PLGA/PHB). The implant prototypes comprise PLGA or PLGA/PHB nonwoven fabrics with designed pore structures to create the best conditions for cell proliferation. The bioactivity of the proposed implants was enhanced by introducing a hydroxyapatite material and a biologically active agent, namely, growth factor IGF1, encapsulated in calcium alginate microspheres. To assess the biocompatibility and bioactivity, allergenic tests and an assessment of the local reaction of bone tissue after implantation were performed. Comparative studies of local tissue response after implantation into trochanters for a period of 12 months were performed on New Zealand rabbits. Based on the results of the in vivo evaluation of the allergenic effects and the local tissue reaction 12 months after implantation, it was concluded that the two implant prototypes, PLGA + IGF1 and PLGA/PHB + IGF1, were characterized by high biocompatibility with the soft and bone tissues of the tested animals.
机译：该研究的目的是评估由可生物降解的纤维材料制成的骨组织再生的两种新型原型植入物的生物相容性和生物活性。首先是新开发的聚（L-丙交酯 - 共乙酰基），（PLGA），第二个是用合成聚（[R，S] -3-羟基丁酸酯）（PLGA / PHB）的PLGGA的混合物。植入物原型包括PLGA或PLGA / PHB非织造织物，具有设计的孔结构，以为细胞增殖产生最佳条件。通过引入羟基磷灰石材料和生长因子IGF1，即包裹在藻酸钙微球中的生长因子IGF1，增强了所提出的植入物的生物活性。评估生物相容性和生物活性，过敏性试验和对植入后骨组织局部反应的评估。在新西兰兔子进行植入植入转子后局部组织反应的对比研究进行了12个月。基于植入后的过敏作用和局部组织反应的体内评价的结果，得出结论，两种植入式原型，PLGA + IGF1和PLGA / PHB + IGF1的特点是通过高生物相容性与柔软和测试动物的骨组织。

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