...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mutation Research. Reviews in Mutation Research >Ionizing radiation biomarkers in epidemiological studies – An update
【24h】

Ionizing radiation biomarkers in epidemiological studies – An update

机译：流行病学研究中的电离辐射生物标志物 - 更新

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of 100 mSv and dose rates of 10 mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30–60 mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted. One biomarker identified in the final stages of development and as a priority for further research is radiation specific mRNA transcript profiles.
机译：摘要近期流行病学研究突出了暴露于低剂量和低剂量率电离辐射（IR）的有害健康影响（IR）：核工业工人研究表明，累积剂量＆lt中累积剂量后的白血病和实体肿瘤风险增加。每年10岁;儿科患者的研究报道，从计算机断层扫描扫描30-60 MGOS的剂量后，白血病和脑肿瘤的风险增加。然而，关于甚至更低剂量和剂量率的影响发生，古典流行病学研究的功率有限，而且预期大群组内的子集会产生增加的风险。进一步的进展需要整合生物标志物或单个暴露，效果和易感性的生物测定。欧洲Doremi（多学科整合低剂量研究）联盟以前审查了IR流行病学研究的潜在用途的生物标志物。鉴于对低剂量辐射的反应增加的机械理解，目前的评论提供了更新的技术进步和最近的研究。确定了一个关键问题正在决定哪些生物标志物进展。从发现实施的生物标志物开发提供了一种路线图，并用于总结当前拟议生物标志物的流行病学研究的现状。大多数潜在的生物标志物留在发现阶段，对于一些有足够的证据表明，不需要进一步发展。在开发的最终阶段确定的一种生物标志物，作为进一步研究的优先级是辐射特异性mRNA转录物谱。

著录项

  • 来源
  • 作者

    Janet Hall; Penny A. Jeggo; Catharine West; Maria Gomolka; Roel Quintens; Christophe Badie; Olivier Laurent; An Aerts; Nata?a Anastasov; Omid Azimzadeh; Tamara Azizova; Sarah Baatout; Bjorn Baselet; Mohammed A. Benotmane; Eric Blanchardon; Yann Guéguen; Siamak Haghdoost; Mats Harms-Ringhdahl; Julia Hess; Michaela Kreuzer; Dominique Laurier; Ellina Macaeva; Grainne Manning; Eileen Pernot; Jean-Luc Ravanat; Laure Sabatier; Karine Tack; Soile Tapio; Horst Zitzelsberger; Elisabeth Cardis;

  • 作者单位

    Centre de Recherche en Cancérologie de Lyon INSERM 1052 CNRS 5286 Univ Lyon Université Claude;

    Genome Damage and Stability Centre School of Life Sciences University of Sussex;

    Translational Radiobiology Group Institute of Cancer Sciences The University of Manchester;

    Federal Office for Radiation Protection Department of Radiation Protection and Health;

    Radiobiology Unit Belgian Nuclear Research Centre SCK·CEN;

    Cancer Mechanisms and Biomarkers group Radiation Effects Department Centre for Radiation;

    Institut de Radioprotection et de S?reté Nucléaire;

    Radiobiology Unit Belgian Nuclear Research Centre SCK·CEN;

    Helmholtz Zentrum München German Research Center for Environmental Health GmbH Institute of;

    Helmholtz Zentrum München German Research Center for Environmental Health GmbH Institute of;

    Southern Urals Biophysics Institute Clinical Department;

    Radiobiology Unit Belgian Nuclear Research Centre SCK·CEN;

    Radiobiology Unit Belgian Nuclear Research Centre SCK·CEN;

    Radiobiology Unit Belgian Nuclear Research Centre SCK·CEN;

    Institut de Radioprotection et de S?reté Nucléaire;

    Institut de Radioprotection et de S?reté Nucléaire;

    Centre for Radiation Protection Research Department of Molecular Biosciences The Wenner-Gren;

    Centre for Radiation Protection Research Department of Molecular Biosciences The Wenner-Gren;

    Helmholtz Zentrum München German Research Center for Environmental Health GmbH Institute of;

    Federal Office for Radiation Protection Department of Radiation Protection and Health;

    Institut de Radioprotection et de S?reté Nucléaire;

    Radiobiology Unit Belgian Nuclear Research Centre SCK·CEN;

    Cancer Mechanisms and Biomarkers group Radiation Effects Department Centre for Radiation;

    INSERM U897 Université de Bordeaux;

    Laboratoire des Lésions des Acides Nucléiques Univ. Grenoble Alpes INAC-SCIB;

    Commissariat à l'énergie Atomique;

    Institut de Radioprotection et de S?reté Nucléaire;

    Helmholtz Zentrum München German Research Center for Environmental Health GmbH Institute of;

    Helmholtz Zentrum München German Research Center for Environmental Health GmbH Institute of;

    Barcelona Institute of Global Health (ISGlobal) Centre for Research in Environmental Epidemiology;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 变异;
  • 关键词

    Molecular epidemiology; Biomarkers; Ionizing radiation; Effects; Exposure; Individual sensitivity;

    机译：分子流行病学;生物标志物;电离辐射;效果;曝光;个人敏感性;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号