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Metastases

机译:转移

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摘要

Biology of Lymph Node Metastasis: Metastases are the most common non-haematopoietic cause of malignant lymph node (LN) enlargement. Meta-static LN (MLN) may occur in patients with a history of cancer or as a primary clinical manifestation of a neoplastic disease, and fine-needle cytology (FNC) plays a different role in the 2 clinical settings. In the case of a known primary tumour, FNC may confirm the diagnosis and contribute to the clinical staging and prognostic evaluations [1-5]. In cases of unknown primary tumour, FNC may identify or suggest the possible origin of the metastasis [6, 7]. Any malignant tumour can metastasize to LNs, but this occurrence varies greatly on the basis of the tumour type and the different clinical contexts [8]. Carcinoma most frequently produces MLNs, followed by melanoma and germ-cell tumours [6,7]. Sarcoma rarely causes MLN, and central nervous system tumours almost never lead to such an occurrence. Relationships exists between the primary tumour and the MLN in the related anatomical district and the time interval between the primary tumour and MLNs. For instance, papillary thyroid carcinoma (PTC) may produce early anterior cervical MLN, while prostatic carcinoma usually leads to late inguinal-crural MLN.
机译:淋巴结转移的生物学:转移是恶性淋巴结(LN)扩大的最常见的非血包病因。 Meta-静态LN(MLN)可能发生在患有癌症史或作为肿瘤疾病的主要临床表现的患者中,细针细胞学(FNC)在2个临床环境中起不同作用。在已知的主要肿瘤的情况下,FNC可以证实诊断并有助于临床分期和预后评估[1-5]。在未知的原发性肿瘤的情况下,FNC可以识别或表明转移的可能起源[6,7]。任何恶性肿瘤都可以转移到LNS,但这种发生在肿瘤类型和不同的临床上下文的基础上变化很大[8]。癌癌最常产生MLNS,其次是黑素瘤和细胞瘤[6,7]。肉瘤很少导致MLN,中枢神经系统肿瘤几乎从未导致这种发生。在相关解剖区中的主要肿瘤和MLN之间存在关系以及原发性肿瘤和MLNS之间的时间间隔。例如,乳头状甲状腺癌(PTC)可以产生早期的宫颈MLN,而前列腺癌通常会导致晚期腹股沟复杂的MLN。

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