Association of GATA4 sequence variation with alcohol dependence

KarpyakV.M.; WinhamS.J.; BiernackaJ.M.; CunninghamJ.M.; LewisK.A.; GeskeJ.R.; ColbyC.L.; AbulseoudO.A.; Hall-FlavinD.K.; LoukianovaL.L.; SchneeklothT.D.; FryeM.A.; HeitJ.A.; MrazekD.A.

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Association of GATA4 sequence variation with alcohol dependence

机译：GATA4序列变异与酒精依赖关系

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To further explore reports of association of alcohol dependence and response to acamprosate treatment with the GATA4 rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other GATA4 SNPs in 816 alcohol-dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between GATA4 and alcohol dependence at the gene level (P = 0.009) but no association with rs13273672. Further studies are needed to identify potential causal GATA4 variation(s) and the functional mechanism(s) contributing to this association.

机译：为了进一步探讨酒精依赖和对GATA4 rs13273672单核苷酸多态性（SNP）的阿坎酸治疗反应的报道，我们在816个酒精依赖病例和1248个对照中对了这个和10个其他GATA4 SNP进行了基因分型。我们分别测试了酒精依赖与11个SNP的关联，并使用主成分分析对关联进行了全局测试。我们的分析表明，在基因水平上，GATA4与酒精依赖之间存在显着关联（P = 0.009），但与rs13273672没有关联。需要进一步的研究来确定潜在的因果GATA4变异和有助于这种关联的功能机制。

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《Addiction biology》 |2014年第2期|共4页
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KarpyakV.M.; WinhamS.J.; BiernackaJ.M.; CunninghamJ.M.; LewisK.A.; GeskeJ.R.; ColbyC.L.; AbulseoudO.A.; Hall-FlavinD.K.; LoukianovaL.L.; SchneeklothT.D.; FryeM.A.; HeitJ.A.; MrazekD.A.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Alcohol dependence; GATA4; gene level test; genetic association;

机译：酒精依赖;GATA4;基因水平测试;遗传关联;

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1. Association of GATA4 sequence variation with alcohol dependence [J] . KarpyakV.M., WinhamS.J., BiernackaJ.M., Addiction biology . 2014,第2期

机译：GATA4序列变异与酒精依赖关系
2. Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent [J] . Stacey J. Winham, Ulrich W. Preuss, Jennifer R. Geske, Scientific reports. . 2015,第期

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3. Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. [J] . Xu K, Anderson TR, Neyer KM, The pharmacogenomics journal . 2007,第6期

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6. Association of GATA4 sequence variation with alcohol dependence [O] . Victor M. Karpyak, Stacey J. Winham, Joanna M. Biernacka, -1

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7. Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent [O] . Winham, Stacey J., Preuss, Ulrich W., Geske, Jennifer R., 2015

机译：前强啡肽序列变异与酒精依赖和相关性状的相关性是表型特异性和性别依赖性的

Association of GATA4 sequence variation with alcohol dependence

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