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首页> 外文期刊>Addiction biology >Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects.
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Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects.

机译：禁欲的青少年大麻使用者的前额叶皮层形态测定法：细微的性别影响。

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Adult human studies suggest frontal dysfunction associated with chronic marijuana (MJ) use, but due to continued neuromaturation, adult studies may not generalize to adolescents. This study characterized prefrontal cortex (PFC) morphometry in chronic MJ-using adolescents following 1 month of monitored abstinence. Data were collected from MJ users (n = 16) and controls (n = 16) aged 16-18. Extensive exclusionary criteria included co-morbid psychiatric and neurologic disorders. Substance use and anatomical measures were collected after 28 days of monitored abstinence. PFC volumes were ascertained from manual tracing by reliable raters on high-resolution magnetic resonance images. After controlling for lifetime alcohol use, gender and intracranial volume, MJ users did not differ from controls in PFC volume. However, marginal group-by-gender interactions were observed (P < 0.09): female MJ users demonstrated comparatively larger PFC volumes while male MJ users had smaller volumes compared with same-gender controls. Further, group status and total PFC volume interacted in predicting executive functioning (P < 0.05). Among MJ users, smaller PFC total volume was associated with better executive functioning while the opposite pattern was seen among the controls. These preliminary results indicate that gender may moderate the relationship between MJ use and PFC morphometry. Given the relationship between larger PFC total volumes and poorer executive functioning among MJ users, female MJ users may be at increased risk for neurocognitive consequences. Future research will measure PFC gray and white matter separately and follow boys and girls over adolescence to examine the influence of MJ use on neurodevelopment.
机译：成人研究表明，与使用慢性大麻（MJ）相关的额叶功能障碍，但由于持续的神经成熟，成人研究可能无法推广到青少年。这项研究的特点是监测禁酒1个月后使用MJ的慢性青少年前额叶皮层（PFC）形态。数据收集自MJ用户（n = 16）和16-18岁的对照组（n = 16）。广泛的排除标准包括并存的精神病和神经病。在禁食监测28天后收集药物使用和解剖措施。 PFC体积是通过可靠的评分者在高分辨率磁共振图像上的手动跟踪确定的。在控制了终生饮酒量，性别和颅内体积之后，MJ使用者与对照组的PFC体积没有差异。但是，观察到了按性别划分的边际互动（P <0.09）：与同性别对照相比，女性MJ用户展示的PFC量相对较大，而男性MJ用户展示的PFC量则较小。此外，组状态和总PFC量在预测执行功能方面相互影响（P <0.05）。在MJ用户中，较小的PFC总体积与更好的执行功能相关，而在控件之间则看到相反的模式。这些初步结果表明，性别可以缓解MJ使用与PFC形态之间的关系。鉴于MJ用户中较大的PFC总量与较差的执行功能之间的关系，女性MJ用户可能会增加神经认知后果的风险。未来的研究将分别测量PFC灰和白质，并跟踪青春期的男孩和女孩，检查MJ的使用对神经发育的影响。

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