• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Addiction biology >White matter integrity in young smokers: a tract-based spatial statistics study
【24h】

White matter integrity in young smokers: a tract-based spatial statistics study

机译：年轻烟民的白质完整性：基于道的空间统计研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous diffusion tensor imaging (DTI) studies revealed contradictory effects of smoking on fractional anisotropy (FA). Multiple DTI-derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of young smokers. Twenty-three young smokers and 22 age-, education- and gender-matched healthy non-smoking controls participated in this study. Tract-based spatial statistics was employed to investigate the WM microstructure in young smokers by integrating multiple indices, including FA, mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Compared with healthy non-smoking controls, young smokers showed significantly increased FA with increased AD and decreased RD in several brain regions, while no difference in MD was observed. Specifically, the overlapped WM regions with increased FA, increased AD and decreased RD were found in the right posterior limb of the internal capsule, the right external capsule and the right superior corona radiata. Additionally, average FA and RD values in the WM regions mentioned earlier were significantly correlated with pack-years and Fagerstrom Test for Nicotine Dependence, while no correlation in AD was found. The WM tracts with increased FA may be more associated with RD, rather than AD in young smokers. We suggested that WM properties of several fibres in young smokers may be the biomarker as the cumulative effect and severity of nicotine dependence.
机译：先前的扩散张量成像（DTI）研究表明，吸烟对分数各向异性（FA）有矛盾的影响。多个DTI派生的指数可能有助于推断白烟（WM）变化的病理生理类型，并在年轻烟民的整个大脑中提供WM神经病理学的更具体的生物标记。 23名年轻吸烟者和22位年龄，教育程度和性别匹配的健康非吸烟者参加了这项研究。通过整合包括FA，平均扩散率（MD），径向扩散率（RD）和轴向扩散率（AD）在内的多个指标，采用基于区域的空间统计数据来研究年轻吸烟者的WM微观结构。与健康的非吸烟对照组相比，年轻的吸烟者在几个脑区域显示出FA显着增加，AD增加和RD降低，而MD则无差异。具体而言，在内囊的右后肢，右外囊和右上电晕放射线中发现了重叠的WM区，FA升高，AD升高和RD降低。此外，前面提到的WM地区的平均FA和RD值与Pack-years和Fagerstrom尼古丁依赖测试显着相关，而在AD中则没有相关性。在年轻吸烟者中，FA增加的WM道可能与RD相关，而不是与AD相关。我们建议年轻烟民中几种纤维的WM特性可能是尼古丁依赖的累积效应和严重性的生物标志。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号