DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

Sierra Marta I.; Rubio Laura; Bayon Gustavo F.; Cobo Isabel; Menendez Pablo; Morales Paula; Mangas Cristina; Urdinguio Rocio G.; Lopez Virginia; Valdes Adolfo; Vales Gerard; Marcos Ricard; Torrecillas Ramon; Fernandez Agustin F.; Fraga Mario F.

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DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

机译：暴露于多壁碳纳米管的人肺上皮细胞的DNA甲基化变化

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Humans are increasingly exposed to nanoparticles and, although many of their physiological effects have been described, the molecular mechanisms underlying them are still largely unknown. The present study aimed to determine the possible role of certain epigenetic mechanisms in the cellular response of human lung epithelial cells that are triggered by long-term exposure to titanium dioxide nanoparticles (TiO(2)NPs) and multi-walled carbon nanotubes (MWCNTs). The results showed that exposure to TiO(2)NPs had only minor effects on genome-wide DNA methylation. However, we identified 755 CpG sites showing consistent DNA hypomethylation in cells exposed to MWCNTs. These sites were mainly located at low density CpG regions and enhancers, and very frequently on the X chromosome. Our results thus suggest that long-term MWCNT exposure may have important effects on the epigenome.

机译：人类越来越多地暴露于纳米颗粒，虽然已经描述了许多生理效果，但它们的分子机制仍然很大程度上是未知的。本研究旨在确定某些表观遗传机制在通过长期暴露于二氧化钛纳米颗粒（TiO（2）NPS）和多壁碳纳米管（MWCNT）的多次碳纳米粒子（MWCNT）引发的人肺上皮细胞的细胞响应中的可能作用。结果表明，暴露于TiO（2）NPS对基因组宽的DNA甲基化仅产生微小的影响。然而，我们鉴定了755个CPG位点，显示出暴露于MWCNT的细胞中的一致DNA低甲基化。这些网站主要位于低密度CpG区域和增强剂，并且在X染色体上非常经常。因此，我们的结果表明，长期MWCNT暴露可能对表观蛋白酶有重要影响。

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来源
《Nanotoxicology》 |2017年第10期|共14页
作者
Sierra Marta I.; Rubio Laura; Bayon Gustavo F.; Cobo Isabel; Menendez Pablo; Morales Paula; Mangas Cristina; Urdinguio Rocio G.; Lopez Virginia; Valdes Adolfo; Vales Gerard; Marcos Ricard; Torrecillas Ramon; Fernandez Agustin F.; Fraga Mario F.;
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作者单位

Univ Oviedo Inst Invest Sanitaria Principado Asturias ISPA HUCA Canc Epigenet Lab Inst Oncol Asturias IUOPA Oviedo Spain;

Univ Autonoma Barcelona Fac Biociencies Dept Genet &

Microbiol Grp Mutagenesi Barcelona Spain;

Univ Oviedo Inst Invest Sanitaria Principado Asturias ISPA HUCA Canc Epigenet Lab Inst Oncol Asturias IUOPA Oviedo Spain;

ISCIII Ctr Invest Biomed Red Canc CIBERONC Barcelona Spain;

ISCIII Ctr Invest Biomed Red Canc CIBERONC Barcelona Spain;

Univ Oviedo Inst Invest Sanitaria Principado Asturias ISPA HUCA Canc Epigenet Lab Inst Oncol Asturias IUOPA Oviedo Spain;

Univ Oviedo Inst Invest Sanitaria Principado Asturias ISPA HUCA Canc Epigenet Lab Inst Oncol Asturias IUOPA Oviedo Spain;

Univ Oviedo Principado Asturias Nanomat &

Nanotechnol Res Ctr CINN CSIC Asturias Spain;

Univ Oviedo Principado Asturias Nanomat &

Nanotechnol Res Ctr CINN CSIC Asturias Spain;

Univ Oviedo Principado Asturias Nanomat &

Nanotechnol Res Ctr CINN CSIC Asturias Spain;

Univ Autonoma Barcelona Fac Biociencies Dept Genet &

Microbiol Grp Mutagenesi Barcelona Spain;

Univ Autonoma Barcelona Fac Biociencies Dept Genet &

Microbiol Grp Mutagenesi Barcelona Spain;

Univ Oviedo Principado Asturias Nanomat &

Nanotechnol Res Ctr CINN CSIC Asturias Spain;

Univ Oviedo Inst Invest Sanitaria Principado Asturias ISPA HUCA Canc Epigenet Lab Inst Oncol Asturias IUOPA Oviedo Spain;

Univ Oviedo Principado Asturias Nanomat &

Nanotechnol Res Ctr CINN CSIC Asturias Spain;

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正文语种 eng
中图分类基础医学;
关键词
Epigenetics; DNA methylation; nanomaterials; exposure;

机译：表观生物学;DNA甲基化;纳米材料;曝光;

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专利

1. DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes [J] . Sierra Marta I., Rubio Laura, Bayon Gustavo F., Nanotoxicology . 2017,第6a10期

机译：暴露于多壁碳纳米管的人肺上皮细胞的DNA甲基化变化
2. Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells [J] . GuoF., MaN., HoribeY., Toxicology and Applied Pharmacology . 2012,第2期

机译：多壁碳纳米管通过内吞作用诱导人肺上皮细胞的硝化DNA损伤
3. Cytotoxicity of single-walled carbon nanotubes, multi-walled carbon nanotubes, and chrysotile to human lung epithelial cells [J] . Yousef Mohammadian, Seyed Jamaleddin Shahtaheri, Ali Akbar Saboor Yaraghi, Toxicological and Environmental Chemistry . 2013,第5a6期

机译：单壁碳纳米管，多壁碳纳米管和温石棉对人肺上皮细胞的细胞毒性
4. Oxidative Stress-Mediated Pro-Inflammatory Responses in Lung Epithelial Cells Exposed to Multi-Walled Carbon Nanotubes [C] . Han Min, Ye Shefang, Wen Wen, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：氧化应激介导的多壁碳纳米管暴露于肺上皮细胞的促炎反应。
5. Influence of Aspect Ratio and Surface Chemistry of Multi-walled Carbon Nanotubes on Structure and Properties of Multi-walled Carbon Nanotube/Polymer Composite Foams [D] . Chen, Limeng 2010

机译：多壁碳纳米管的长径比和表面化学性质对多壁碳纳米管/聚合物复合泡沫结构和性能的影响
6. Impaired Ciliogenesis in differentiating human bronchial epithelia exposed to non-Cytotoxic doses of multi-walled carbon Nanotubes [O] . Ryan J. Snyder, Salik Hussain, Charles J. Tucker, 2017

机译：暴露于无细胞毒性剂量的多壁碳纳米管的人支气管上皮的分化中纤毛生成受损。
7. Cytotoxic and inflammatory responses of human lung cells exposed to multi-walled carbon nanotubes [O] . Nilsen Lone 2011

机译：暴露于多壁碳纳米管的人肺细胞的细胞毒性和炎症反应
8. Assessment of Human Lung Macrophages After Exposure to Multi-Walled Carbon Nanotubes. Part 2. DNA Damage. [R] . Zhu, L., Schrand, A. M., Voevodin, A. A., 2011

机译：暴露于多壁碳纳米管后人肺巨噬细胞的评估。第2部分DNa损伤。

DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

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