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首页> 外文期刊>Nature cell biology >DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres
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DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

机译：DNA复制作为纠错机制，通过将CENP-A限制为CENTROMERS来维持CENTROMERE身份

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摘要

Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites are identified within the megabase-long, repetitive a-satellite DNAs at each centromere. CENP-A is shown in early G1 to be assembled into nucleosomes within each centromere and onto 11,390 transcriptionally active sites on the chromosome arms. DNA replication is demonstrated to remove ectopically loaded, non-centromeric CENP-A. In contrast, tethering of centromeric CENP-A to the sites of DNA replication through the constitutive centromere associated network (CCAN) is shown to enable precise reloading of centromere-bound CENP-A onto the same DNA sequences as in its initial prereplication loading. Thus, DNA replication acts as an error correction mechanism for maintaining centromere identity through its removal of non-centromeric CENP-A coupled with CCAN-mediated retention and precise reloading of centromeric CENP-A.
机译：染色质与组蛋白H3变体CENP-A组装是人征统称身份的遗传表观遗传决定因素。使用基因组 - 宽的映射和参考模型对于23个人中罗米，CENP-A结合位点在每个Centromere的兆族酶 - 长的重复A卫星DNA内鉴定。 CENP-A在较早的G1中示出，待组装成每个CEMROMERE内的核体，并在染色体臂上上的11,390个转录活性位点。证明DNA复制以除去不同的负载，非厘米CENP-A。相反，通过组成符号相关网络（CCAN）的焦化CENP-A对DNA复制位点的束缚，使得将CEDROMER-CONDED CENP-A精确地重新加载到与其初始经细菌负载中相同的DNA序列。因此，DNA复制作为误差校正机构，通过其去除非CENTOMERIC CENP-A与CCAN介导的保持和精确重新加载厘米CENP-A的纠错机制。

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