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Human brain evolution: transcripts, metabolites and their regulators.

机译:人脑进化:转录物,代谢产物及其监管机构。

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What evolutionary events led to the emergence of human cognition? Although the genetic differences separating modern humans from both non-human primates (for example, chimpanzees) and archaic hominins (Neanderthals and Denisovans) are known, linking human-specific mutations to the cognitive phenotype remains a challenge. One strategy is to focus on human-specific changes at the level of intermediate phenotypes, such as gene expression and metabolism, in conjunction with evolutionary changes in gene regulation involving transcription factors, microRNA and proximal regulatory elements. In this Review we show how this strategy has yielded some of the first hints about the mechanisms of human cognition.
机译:什么进化事件导致人类认知的出现? 尽管已知将现代人类(例如,黑猩猩)和古代母素(Neanderthals和DeNisovans)分离出现代人类的遗传差异,但将人特异性突变与认知表型联系起来仍然是挑战。 一种策略要关注中间表型水平的人体特异性变化,例如基因表达和代谢的水平,同时与涉及转录因子,微稻草和近端调节元件的基因调节的进化变化。 在这篇综述中,我们展示了该策略如何产生关于人类认知机制的一些暗示。

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