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Neurodegenerative disorders: Parkinson's disease reveals hidden depths.

机译:神经变性疾病:帕金森病揭示了隐藏的深度。

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Deep brain stimulation (DBS) applied to the subthalamic nucleus (STN) has proved to be useful in the treatment of Parkinson's disease. It was thought that the therapeutic action of DBS involved a direct inhibitory action on the STN. Li et al. simultaneously recorded local field potentials and single-unit activities from the motor cortex of freely moving Parkinsonian rats during DBS applied to the STN. They found that DBS has a more widespread influence: it induces antidromic action potentials from the STN that normalize pathological cortical β-oscillations in the motor cortex, and it is this that is thought to underlie the therapeutically beneficial effect of this treatment
机译:应用于亚饱和核(STN)的深脑刺激(DBS)已被证明是可用于治疗帕金森病的治疗。 据认为,DBS的治疗作用涉及STN上的直接抑制作用。 李等人。 在应用于STN的DBS期间,同时记录了从自由移动的帕金森大鼠的电机皮层的本地电位和单位活动。 他们发现DBS具有更广泛的影响:它引起了来自STN的抗体动作电位,该抗体动作电位在马达皮质中规范化病理皮质β-振荡,这是认为这种治疗的治疗有益效果

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