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首页> 外文期刊>Nature nanotechnology >Evaluating the potential of using quantum dots for monitoring electrical signals in neurons
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Evaluating the potential of using quantum dots for monitoring electrical signals in neurons

机译：评估使用量子点进行神经元中电信号的电位

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Success in the projects aimed at providing an advanced understanding of the brain is directly predicated on making critical advances in nanotechnology. This Perspective addresses the unique interface of neuroscience and nanomaterials by considering the foundational problem of sensing neuron membrane voltage and offers a potential solution that may be facilitated by a prototypical nanomaterial. Despite substantial improvements, the visualization of instantaneous voltage changes within individual neurons, whether in cell culture or in vivo, at both the single-cell and network level at high speed remains complex and problematic. The unique properties of semiconductor quantum dots (QDs) have made them powerful fluorophores for bioimaging. What is not widely appreciated, however, is that QD photoluminescence is exquisitely sensitive to proximal electric fields. This property should be suitable for sensing voltage changes that occur in the active neuronal membrane. Here, we examine the potential role of QDs in addressing the important challenge of real-time optical voltage imaging.
机译：旨在提供对大脑的先进了解的项目中的成功将直接提出在纳米技术的关键进步方面取决于对大脑进行巨大的预测。该透视通过考虑感测神经元膜电压的基础问题，提供了神经科学和纳米材料的独特界面，并提供了可以通过原型纳米材料促进的潜在溶液。尽管有大量的改进，但在高速下，单个细胞和网络水平的单个神经元内瞬时电压变化的可视化仍然是复杂的并且有问题。半导体量子点（QDS）的独特性质使它们具有强大的生物体荧光团。然而，未得到广泛欣赏的是，QD光致发光对近端电场非常敏感。该特性应适用于主动神经元膜中发生的电压变化。在这里，我们研究QDS在解决实时光电压成像的重要挑战方面的潜在作用。

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