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Advanced tools for the safety assessment of nanomaterials

机译：纳米材料安全评估的先进工具

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摘要

Engineered nanomaterials (ENMs) have tremendous potential to produce beneficial technological impact in numerous sectors in society. Safety assessment is, of course, of paramount importance. However, the myriad variations of ENM properties makes the identification of specific features driving toxicity challenging. At the same time, reducing animal tests by introducing alternative and/or predictive in vitro and in silico methods has become a priority. It is important to embrace these new advances in the safety assessment of ENMs. Indeed, remarkable progress has been made in recent years with respect to mechanism-based hazard assessment of ENMs, including systems biology approaches as well as high-throughput screening platforms, and new tools are also emerging in risk assessment and risk management for humans and the environment across the whole life-cycle of nano-enabled products. Here, we highlight some of the key advances in the hazard and risk assessment of ENMs.
机译：工程纳米材料（ENM）对社会众多部门产生了巨大的潜力。 当然，安全评估是至关重要的。 然而，恩姆姆属性的无数变化使得探测毒性挑战的特定特征。 同时，通过在体外和硅方法中引入替代和/或预测性来降低动物测试已成为优先级。 在敌人的安全评估中拥抱这些新进步非常重要。 实际上，近年来就蜗牛机制的危害评估而近年来取得了显着进展，包括系统生物学方法以及高吞吐量筛查平台，以及对人类的风险评估和风险管理中的新工具也出现了新的工具 环境跨越纳米产品的整个生命周期的环境。 在这里，我们突出了危害危害和风险评估的一些关键进展。

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