A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

OkazakiT.; ChikumaS.; IwaiY.; FagarasanS.; HonjoT.

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A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

机译：免疫应答的变阻器：PD-1的独特性质及其对临床应用的优点

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PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.

机译：PD-1，在抗原刺激的T细胞和B细胞上表达的负核心体似乎是免疫应答的“变阻性”。 PD-1功能的分子机制与PD-1缺陷小鼠的轻度，慢性和菌株特异性自身免疫表型相反，与免疫调节受体CTLA-4缺乏的小鼠的破坏性致命的自身免疫疾病相反，表明PD-1的免疫调节是相当抗原特异性的，主要是细胞内在。这种独特的特性使PD-1成为免疫疗法的强大目标，具有高效的癌症治疗临床应用。

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《Nature immunology》 |2013年第12期|共7页
作者
OkazakiT.; ChikumaS.; IwaiY.; FagarasanS.; HonjoT.;
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作者单位

Division of Immune Regulation Institute for Genome Research University of Tokushima Tokushima;

Department of Immunology and Genomic Medicine Graduate School of Medicine Kyoto University Kyoto;

Department of Molecular Biology School of Medicine University of Occupational and Environmental;

Laboratory for Mucosal Immunity Center for Integrative Medical Sciences IMS RIKEN Yokohama;

Department of Immunology and Genomic Medicine Graduate School of Medicine Kyoto University Kyoto;

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正文语种 eng
中图分类医学免疫学;
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8. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. [O] . Okazaki Taku, Chikuma Shunsuke, Iwai Yoshiko, 2013

机译：用于免疫反应的变阻器：PD-1的独特特性及其在临床应用中的优势。

A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

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