Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1

SpoonerC.J.; LeschJ.; YanD.; KhanA.A.; AbbasA.; Ramirez-CarrozziV.; ZhouM.; SorianoR.; Eastham-AndersonJ.; DiehlL.; LeeW.P.; ModrusanZ.; PappuR.; XuM.; DevossJ.; SinghH.

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Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1

机译：转录决定因素GFI1的2型先天淋巴细胞的规范

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Type 2 innate lymphoid cells (ILC2 cells) participate in host defense against helminth parasites and in allergic inflammation. Given their functional relatedness to type 2 helper T cells (T H 2 cells), we explored whether Gfi1 acts as a shared transcriptional determinant in ILC2 cells. Gfi1 promoted the development of ILC2 cells and controlled their responsiveness during infection with Nippostrongylus brasiliensis and protease allergen-induced lung inflammation. Gfi1 'preferentially' regulated the responsiveness of ILC2 cells to interleukin 33 (IL-33) by directly activating Il1rl1, which encodes the IL-33 receptor (ST2). Loss of Gfi1 in activated ILC2 cells resulted in impaired expression of the transcription factor GATA-3 and a dysregulated genome-wide effector state characterized by coexpression of IL-13 and IL-17. Our findings establish Gfi1 as a shared determinant that reciprocally regulates the type 2 and IL-17 effector states in cells of the innate and adaptive immune systems.

机译：2型先天淋巴细胞（ILC2细胞）参与对蠕虫寄生虫和过敏性炎症的宿主防御。鉴于其功能相关性与型辅助T细胞（T H 2细胞）鉴定，我们探讨了GFI1是否充当ILC2细胞中的共同转录决定蛋白。 GFI1促进了ILC2细胞的发展，并在用Nippostrongylus Brasiliensis和蛋白酶过敏原诱导的肺炎感染期间控制它们的反应性。通过直接激活IL1R11，GFI1'优先对ILC2细胞对白细胞介素33（IL-33）的反应性进行调节，该IL1RL1编码IL-33受体（ST2）。活化ILC2细胞中GFI1的丧失导致转录因子GATA-3的表达受损和表现的失调基因组静脉效应状态，其特征在于IL-13和IL-17。我们的研究结果建立了GFI1作为共同的决定因素，相互调节先天和自适应免疫系统的细胞中的2型和IL-17效应态。

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《Nature immunology》 |2013年第12期|共8页
作者
SpoonerC.J.; LeschJ.; YanD.; KhanA.A.; AbbasA.; Ramirez-CarrozziV.; ZhouM.; SorianoR.; Eastham-AndersonJ.; DiehlL.; LeeW.P.; ModrusanZ.; PappuR.; XuM.; DevossJ.; SinghH.;
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作者单位

Department of Discovery Immunology Genentech South San Francisco CA United States;

Translational Immunology Genentech South San Francisco CA United States;

Translational Immunology Genentech South San Francisco CA United States;

Institute for Systems and Genomics Biology Department of Human Genetics University of Chicago;

Department of Bioinformatics Genentech South San Francisco CA United States;

Department of Discovery Immunology Genentech South San Francisco CA United States;

Translational Immunology Genentech South San Francisco CA United States;

Department of Molecular Biology Genentech South San Francisco CA United States;

Center for Advanced Light Microscopy Genentech South San Francisco CA United States;

Department of Pathology Genentech South San Francisco CA United States;

Translational Immunology Genentech South San Francisco CA United States;

Department of Molecular Biology Genentech South San Francisco CA United States;

Department of Discovery Immunology Genentech South San Francisco CA United States;

Translational Immunology Genentech South San Francisco CA United States;

Translational Immunology Genentech South San Francisco CA United States;

Department of Discovery Immunology Genentech South San Francisco CA United States Division of;

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正文语种 eng
中图分类医学免疫学;
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1. Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1 [J] . SpoonerC.J., LeschJ., YanD., Nature immunology . 2013,第12期

机译：转录决定子Gfi1对2型先天性淋巴细胞的规范
2. A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. [J] . Spooner CJ, Cheng JX, Pujadas E Immunity . 2009,第4期

机译：一个涉及转录因子PU.1和Gfi1的递归网络可协调先天性和适应性免疫细胞的命运。
3. Lineage specification in innate lymphocytes [J] . Arundhoti Das, Christelle Harly, Qi Yang, Cytokine & growth factor reviews . 2018,第期

机译：先天淋巴细胞中的谱系规范
4. Genome-Wide Discovery of Modulators of Transcriptional Interactions in Human B Lymphocytes [C] . Kai Wang, Ilya Nemenman, Nilanjana Banerjee, Annual International Conference on Research in Computational Molecular Biology(RECOMB 2006); 20060402-05; Venice(IT) . 2006

机译：人类B淋巴细胞转录相互作用调控因子的全基因组发现
5. The evolution of transcription regulatory networks governing cell-type specification. [D] . Booth, Lauren Nicole. 2011

机译：转录调控网络控制细胞类型规范的演变。
6. Lineage specification in innate lymphocytes [O] . Arundhoti Das, Christelle Harly, Qi Yang, -1

机译：先天性淋巴细胞的血统规范
7. A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell Fates [O] . Spooner Chauncey J., Cheng Jason X., Pujadas Elisabet, 2009

机译：一个涉及转录因子PU.1和Gfi1的递归网络协调先天性和适应性免疫细胞的命运。
8. Studies on Non-H-2 Linked Lymphocyte Activating Determinants. I. Description of the Cell Type Bearing the MLS Product. [R] . Ahmed, A., Scher, I., Smith, A. H., 1976

机译：非H-2连接淋巴细胞激活决定因素的研究。 I.带有mLs产品的细胞类型的描述。

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1

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