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首页> 外文期刊>Nature immunology >Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
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Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression

机译：通过启动ZFP292表达，ILC3维持需要长的非划分RNA LNCKDM2B

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摘要

Innate lymphoid cells (ILCs) communicate with other hematopoietic and nonhematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How ILC lineages develop and are maintained remains largely unknown. In this study we observed that a divergent long noncoding RNA (lncRNA), lncKdm2b, was expressed at high levels in intestinal group 3 ILCs (ILC3s). LncKdm2b deficiency in the hematopoietic system led to reductions in the number and effector functions of ILC3s. LncKdm2b expression sustained the maintenance of ILC3s by promoting their proliferation through activation of the transcription factor Zfp292. Mechanistically, lncKdm2b recruited the chromatin organizer Satb1 and the nuclear remodeling factor (NURF) complex onto the Zfp292 promoter to initiate its transcription. Deletion of Zfp292 or Bptf also abrogated the maintenance of ILC3s, leading to susceptibility to bacterial infection. Therefore, our findings reveal that lncRNAs may represent an additional layer of regulation of ILC development and function.
机译：先天淋巴细胞（ILCS）与其他造血和非发育细胞连通，以调节免疫，炎症和组织稳态。 ILC谱系如何发展和维护仍然很大程度上是未知数。在该研究中，我们观察到，在肠组3 ILC（ILC3S）中高水平表达发散的长非典型RNA（LNCRNA），LNCKDM2B。 LNCKDM2B造血系统的缺陷导致ILC3S的数量和效应功能的降低。通过通过激活转录因子ZFP292，LNCKDM2B表达通过促进其增殖来维持ILC3。机械地，LNCKDM2B将染色质组织者SATB1和核重塑因子（NURF）复合物招募到ZFP292启动子上以引发其转录。删除ZFP292或BPTF还废除了ILC3的维持，导致细菌感染的易感性。因此，我们的研究结果表明，LNCRNA可以代表ILC发育和功能的额外调节层。

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  • 来源
    《Nature immunology》 |2017年第5期|共10页
  • 作者

    Liu Benyu; Ye Buqing; Yang Liuliu; Zhu Xiaoxiao; Huang Guanling; Zhu Pingping; Du Ying; Wu Jiayi; Qin Xiwen; Chen Runsheng; Tian Yong; Fan Zusen;

  • 作者单位

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Inst Biophys Key Lab RNA Biol Beijing Peoples R China;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

    Univ Chinese Acad Sci Beijing Peoples R China;

    Univ Chinese Acad Sci Beijing Peoples R China;

    Chinese Acad Sci Ctr Excellence Biomacromol Key Lab Infect &

    Immun Inst Biophys Beijing;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
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