A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

Heinze Susanne; Tran Binh Giang; Kan Andrey; Marchingo Julia M.; Lye Bryan K.; Corcoran Lynn M.; Hodgkin Philip D.

首页> 外文期刊>Nature immunology >A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

【24h】

A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

机译：Myc依赖性分割定时器补充了一种细胞死亡计时器来调节T细胞和B细胞应答

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response. Here we report that such control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical threshold. The changing pattern of the level of Myc was not affected by cell division, which identified the regulating mechanism as a cell-intrinsic, heritable temporal controller. Overexpression of Myc in stimulated T cells and B cells did not sustain cell proliferation indefinitely, as a separate 'time-to-die' mechanism, also heritable, was programmed after lymphocyte activation and led to eventual cell loss. Together the two competing cell-intrinsic timed fates created the canonical T cell and B cell immune-response pattern of rapid growth followed by loss of most cells. Furthermore, small changes in these timed processes by regulatory signals, or by oncogenic transformation, acted in synergy to greatly enhance cell numbers over time.

机译：T淋巴细胞和B淋巴细胞整合激活信号以控制其增殖性反应的尺寸。在这里，我们报告说，这种控制是通过定时变化来实现的细胞周期调节原子癌蛋白MYC的生产率，分裂停止时，MICC水平低于临界门槛。 MYC水平的变化模式不受细胞分裂的影响，该细胞分裂鉴定为细胞内在，遗传时间控制器的调节机制。在刺激的T细胞和B细胞中，MyC的过度表达无限期地没有维持细胞增殖，作为单独的“时间 - 死亡”机制，也可以在淋巴细胞激活后编程，并导致最终的细胞损失。两种竞争的细胞内在定时命名在一起创造了快速生长的规范T细胞和B细胞免疫反应模式，然后丧失了大多数细胞。此外，通过调节信号或致癌转化进行这些定时过程的小变化，在协同作用中作用，以随着时间的推移大大提高细胞数。

著录项

来源
《Nature immunology》 |2017年第1期|共8页
作者
Heinze Susanne; Tran Binh Giang; Kan Andrey; Marchingo Julia M.; Lye Bryan K.; Corcoran Lynn M.; Hodgkin Philip D.;
展开▼
作者单位

Walter &

Eliza Hall Inst Med Res Div Immunol Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Div Immunol Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Div Immunol Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Div Immunol Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Div Immunol Parkville Vic Australia;

Univ Melbourne Dept Med Biol Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Div Immunol Parkville Vic Australia;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses [J] . Heinze Susanne, Tran Binh Giang, Kan Andrey, Nature immunology . 2017,第1期

机译：Myc依赖性分割定时器补充了一种细胞死亡计时器来调节T细胞和B细胞应答
2. Cell-Intrinsic Timers and Thyroid Hormone Regulate the Probability of Cell-Cycle Withdrawal and Differentiation of Oligodendrocyte Precursor Cells [J] . Fen-Biao Gao, James Apperly, Martin Raff Developmental biology . 1998,第1期

机译：细胞固有计时器和甲状腺激素调节少突胶质前体细胞的细胞周期退出和分化的可能性。
3. p27(Kip1) alters the response of cells to mitogen and is part of acell-intrinsic timer that arrests the cell cycle and initiatesdifferentiation [J] . Durand B., Fero ML., Roberts JM., Current Biology: CB . 1998,第8期

机译：p27（Kip1）改变细胞对有丝分裂原的反应，并且是细胞内在计时器的一部分，该计时器可阻止细胞周期并启动分化
4. Analysing the floatability of quartz with hexyl-amine cellulose nanocrystals using a novel automated contact timer apparatus [C] . Robert Hartmann, Rodrigo Serna-Guerrero International Flotation Conference . 2019

机译：用新型自动接触定时器装置分析石英与己基胺纤维素纳米晶体的可浮动性
5. A novel approach to control and regulate the classical complement pathway: Highly specific inhibition of C1q globular head binding to human IgG using an engineered single chain antibody variable fragment; recruiting C1q to HER2 /neu positive cells using truncated bispecific antibodies [D] . Hwang, Hee Young 2007

机译：一种控制和调节经典补体途径的新方法：使用工程化的单链抗体可变片段高度特异性地抑制C1q球头与人IgG的结合；使用截短的双特异性抗体将C1q募集到HER2 / neu阳性细胞
6. Human Dendritic Cells Express the Complement Receptor Immunoglobulin Which Regulates T Cell Responses [O] . Usma Munawara, Khalida Perveen, Annabelle G. Small, 2019

机译：人树突细胞表达调节T细胞应答的补体受体免疫球蛋白
7. Cell-Intrinsic Timers and Thyroid Hormone Regulate the Probability of Cell-Cycle Withdrawal and Differentiation of Oligodendrocyte Precursor Cells [O] . Gao Fen-Biao, Apperly James, Raff Martin 1998

机译：细胞固有计时器和甲状腺激素调节少突胶质前体细胞的细胞周期退出和分化的可能性。
8. Electrolytic Cell Timers for Balloon-Borne Applications [R] . Anderson, G. 1970

机译：用于气球应用的电解电池定时器

A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

摘要

著录项

相似文献

相关主题

期刊订阅