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首页> 外文期刊>Nature immunology >Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
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Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

机译：先天免疫细胞参数的自然变化优先受到遗传因素的驱动

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摘要

The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases.
机译：循环免疫细胞的量化和表征提供人体健康和疾病的关键指标。为了确定环境和遗传因素对稳态条件中先天和自适应免疫细胞参数变异的相对效果，我们将血白细胞的标准化流式细胞术结合了1,000个健康，无关的西欧血统无关的血液白细胞和基因组DNA基因分型。我们发现吸烟，随着年龄，性别和潜在的患有细胞瘤病毒的感染，是影响人免疫细胞参数变异的主要非遗传因素。基因组 - 宽协会研究166个免疫蛋白型鉴定了15个基因座，其显示出疾病相关变种的富集。最后，我们证明了先天细胞的参数比遗传变异更强烈地控制，而不是主要是环境暴露所驱动的自适应细胞。我们的数据建立了将在免疫学中产生新假设的资源，并突出了先天免疫在常见自身免疫疾病易感性中的作用。

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