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Feeling stressed? It might be your T cells

机译:感到压力? 它可能是你的t细胞

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The link between cancer and the nervous system has attracted the attention of oncologists and psychiatrists for decades. It is known that patients facing the challenge of cancer diagnosis and therapy often require psychiatric intervention. Although behavioral changes are attributed to emotional stress, studies have indicated a physiological link between the central nervous system (CNS) and the antitumor immune response1. There is now evidence of a role for stress-response-induced neurotransmitters and hormones in the growth of tumors and in the compromise of antitumor immunity, which are mediated by changes in cellular and systemic metabolic pathways2. In this issue of Nature Immunology, Miyajima et al. show that abolishing expression of the inhibitory receptor PD-1 might affect the CNS and lead to anxiety-like behavior and exacerbated fear.
机译:癌症与神经系统之间的联系吸引了肿瘤学家和精神科医生的关注数十年。 众所周知,患有癌症诊断和治疗挑战的患者往往需要精神疗效。 虽然行为变化归因于情绪应激,但研究表明中枢神经系统(CNS)和抗肿瘤免疫应答1之间的生理联系。 现在有证据表明应激响应诱导的神经递质和激素在肿瘤生长中的作用以及抗肿瘤免疫力的折衷,这是通过细胞和全身代谢途径2的变化介导的。 在这个问题的自然免疫学中,Miyajima等。 表明,废除抑制受体PD-1的表达可能影响CNS并导致焦虑的行为和加剧恐惧。

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