Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

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Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

机译：通过Cyld的NLRP6炎症的脱硫致命地调节肠炎症

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NLRP6 is highly expressed in the gut; however, persistent NLRP6 activation can lead to excessive IL-18 production and intestinal bowel disease. Venuprasad and colleagues identify the K63-linked ubiquitin deubiquitinase Cyld as a negative regulator of NLRP6.

机译：NLRP6在肠道中高度表达; 然而，持续的NLRP6激活可以导致过度的IL-18生产和肠道疾病。 venupraSad和同事识别K63连接的泛素脱硫蛋白酶Cyld作为NLRP6的负调节剂。

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《Nature immunology》 |2020年第6期|共20页
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正文语种 eng
中图分类医学免疫学;
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1. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation [J] . Nature immunology . 2020,第6期

机译：通过Cyld的NLRP6炎症的脱硫致命地调节肠炎症
2. Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity [J] . PyB.F., KimM.-S., Vakifahmetoglu-NorbergH., Molecular cell . 2013,第2期

机译：BRCC3对NLRP3的去泛素化可严格调节炎症小体活性。
3. PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer [J] . Marianne R. Spalinger, Roberto Manzini, Larissa Hering, Cell Reports . 2018,第7期

机译：PTPN2调节炎症小体活化并控制肠道炎症和结肠癌的发作。
4. FOOD FACTORS THAT REGULATE INTESTINAL INFLAMMATION: EVALUATION OF THE FACTORS BY USING A COCULTURE SYSTEM [C] . Hideo Satsu, Makoto Shimizu Annual Meeting of the Japanese Association for Animal Cell Technology . 2006

机译：调节肠炎症的食物因素：通过使用共核系统评估因素
5. Thymic T Cells and Gut Microbiota Crosstalk: Regulating Intestinal and Hepatic Inflammation [D] . Weinstein, Erica Gabrielle 2015

机译：胸腺T细胞和肠道菌群的串扰：调节肠道和肝脏炎症。
6. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling [O] . Maayan Levy, Christoph A. Thaiss, David Zeevi, -1

机译：微生物调节的代谢物通过调节NLRP6炎症小体信号传导来塑造肠道微环境
7. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling [O] . Levy Maayan, Thaiss Christoph A., Zeevi David, 2015

机译：微生物调节的代谢物通过调节NLRP6炎性体信号传导来塑造肠道微环境。

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

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