Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis

Sato Ryota; Kato Akihisa; Chimura Takahiko; Saitoh Shin-Ichiroh; Shibata Takuma; Murakami Yusuke; Fukui Ryutaro; Liu Kaiwen; Zhang Yun; Arii Jun; Sun-Wada Ge-Hong; Wada Yoh; Ikenoue Tsuneo; Barber Glen N.; Manabe Toshiya; Kawaguchi Yasushi; Miyake Kensuke

首页> 外文期刊>Nature immunology >Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis

【24h】

Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis

机译：通过增强TLR3-MTORC2轴来调节HERPESVIRUS脑炎

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

TLR3 is a sensor of double-stranded RNA that is indispensable for defense against infection with herpes simplex virus type 1 (HSV-1) in the brain. We found here that TLR3 was required for innate immune responses to HSV-1 in neurons and astrocytes. During infection with HSV-1, TLR3 recruited the metabolic checkpoint kinase complex mTORC2, which led to the induction of chemokines and trafficking of TLR3 to the cell periphery. Such trafficking enabled the activation of molecules (including mTORC1) required for the induction of type I interferons. Intracranial infection of mice with HSV-1 was exacerbated by impairment of TLR3 responses with an inhibitor of mTOR and was significantly 'rescued' by potentiation of TLR3 responses with an agonistic antibody to TLR3. These results suggest that the TLR3-mTORC2 axis might be a therapeutic target through which to combat herpes simplex encephalitis.

机译：TLR3是双链RNA的传感器，可防止在大脑中使用疱疹病毒1（HSV-1）感染1型（HSV-1）。我们在此发现，在神经元和星形胶质细胞中对HSV-1的先天免疫应答需要TLR3。在用HSV-1感染期间，TLR3募集了代谢检查点激酶复合MTORC2，其导致趋化因子和贩运TLR3到细胞周边。这种贩运使得能够激活I型干扰素所需的分子（包括MTORC1）。通过对MTOR抑制剂的TLR3响应的损害，通过TLR3反应的损伤加剧了HSV-1的颅内感染，通过与TLR3的激动抗体的TLR3响应的增强显着“救出”。这些结果表明，TLR3-MTORC2轴可能是用于对抗单纯疱疹性脑炎的治疗靶标。

著录项

来源
《Nature immunology》 |2018年第10期|共12页
作者
Sato Ryota; Kato Akihisa; Chimura Takahiko; Saitoh Shin-Ichiroh; Shibata Takuma; Murakami Yusuke; Fukui Ryutaro; Liu Kaiwen; Zhang Yun; Arii Jun; Sun-Wada Ge-Hong; Wada Yoh; Ikenoue Tsuneo; Barber Glen N.; Manabe Toshiya; Kawaguchi Yasushi; Miyake Kensuke;
展开▼
作者单位

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Mol Virol Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Neuronal Network Dept Basic Med Sci Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Mol Virol Dept Microbiol &

Immunol Tokyo Japan;

Doshisha Womens Coll Fac Pharmaceut Sci Dept Biochem Kyoto Japan;

Osaka Univ Inst Sci &

Ind Res Div Biol Sci Osaka Japan;

Univ Tokyo Inst Med Sci Div Clin Genome Res Adv Clin Res Ctr Tokyo Japan;

Univ Miami Miller Sch Med UM Sylvester Canc Ctr Miami FL 33136 USA;

Univ Tokyo Inst Med Sci Div Neuronal Network Dept Basic Med Sci Tokyo Japan;

Univ Tokyo Inst Med Sci Div Mol Virol Dept Microbiol &

Immunol Tokyo Japan;

Univ Tokyo Inst Med Sci Div Innate Immun Dept Microbiol &

Immunol Tokyo Japan;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis [J] . Sato Ryota, Kato Akihisa, Chimura Takahiko, Nature immunology . 2018,第10期

机译：通过增强TLR3-MTORC2轴来调节HERPESVIRUS脑炎
2. Human herpesvirus 6 encephalitis in patients administered mycophenolate mofetil as prophylaxis for graft-versus-host disease after allogeneic hematopoietic stem cell transplantation [J] . Inui Yumiko, Yakushijin Kimikazu, Okamura Atsuo, Transplant infectious disease: an official journal of the Transplantation Society . 2019,第1期

机译：患者的人疱疹病毒6脑炎患者霉酚酸酯MOFETil作为异种造血干细胞移植后的移植物与宿主疾病的预防
3. Foscarnet against human herpesvirus (HHV)-6 reactivation after allo-SCT: Breakthrough HHV-6 encephalitis following antiviral prophylaxis [J] . OgataM., SatouT., InoueY., Bone marrow transplantation . 2013,第2期

机译：异代SCT后的膦甲酸酯抗人类疱疹病毒（HHV）-6活化：抗病毒预防后突破HHV-6脑炎
4. Comparative Epidemiologies of Eastern Equine Encephalitis Virus, Western Equine Encephalitis Virus, Venezuelan Equine Encephalitis Virus, and West Nile Virus [C] . Charles H. Calisher Annual Meeting of the American Society for Veterinary Clinical Pathology . 2004

机译：东部大雄脑炎病毒，西马脑炎病毒，委内瑞拉脑脑炎病毒和西尼罗河病毒的比较流行病学
5. RNA Interference for the Prophylaxis of Combat Trauma-Induced Heterotopic Ossification. [D] . Hsu, Eric Wei. 2014

机译：RNA干扰预防战斗创伤引起的异位骨化。
6. SDF-1α/CXCR4 axis is involved in glucose-potentiated proliferation and chemotaxis in rat vascular smooth muscle cells [O] . Wei Jie, Xiaoyan Wang, Yuhong Zhang, 2010

机译：SDF-1α/ CXCR4轴参与大鼠血管平滑肌细胞中葡萄糖增强的增殖和趋化性
7. Anti-N-methyl-D-aspartate receptor encephalitis 8 years after serial herpes simplex virus type 1 and human herpesvirus type 7 encephalitis [O] . Yoonhyuk Jang, Jeong-Min Kim, Jangsup Moon, 2020

机译：抗N-甲基-D-天冬氨酸受体脑炎连续疱疹病毒1型和人疱疹病毒型7型脑炎
8. 'Herpesvirus hominis' Encephalitis and Retinitis. [R] . Minckler, D. S., McLean, E. B., Shaw, C. M., 1974

机译：'疱疹病毒人类'脑炎和视网膜炎。

Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis

摘要

著录项

相似文献

相关主题

期刊订阅