...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nephrology. >Use of a new end‐stage kidney disease risk calculator in the Kidney Disease Improving Global Outcomes Kidney Disease Improving Global Outcomes guideline to evaluate the impact of different living kidney donor candidate assessments
【24h】

Use of a new end‐stage kidney disease risk calculator in the Kidney Disease Improving Global Outcomes Kidney Disease Improving Global Outcomes guideline to evaluate the impact of different living kidney donor candidate assessments

机译：在肾病中使用新的末期肾脏疾病风险计算器，提高全球结果肾病改善全球结果指南，以评估不同生活肾脏捐助者候选评估的影响

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Aim The Kidney Disease Improving Global Outcomes (KDIGO) guideline recommends the incorporation of a new risk calculator that quantifies the end‐stage kidney disease (ESKD) risk based on a composite profile of risk factors in living kidney donor candidates (LKDC). We compared the ESKD risk estimates in previously declined versus accepted LKDC to evaluate the predictive capacity and potential impact of this tool. Methods Baseline 15 year and lifetime ESKD risk estimates without donation were calculated using the risk calculator for LKDC assessed from two centres between 2007 and 2015. LKDC suitability based on the proposed KDIGO and the existing Caring for Australasians with Renal Impairment national guidelines was compared. Results Median 15 year ESKD risk was 0.14% (IQR 0.09–0.31%) in declined LKDC ( n =59) versus 0.10% (0.07–0.14%) in accepted LKDC ( n =89) ( P 0.001). Lifetime risk was similar: 0.39% (0.23–0.80%) versus 0.35% (0.22–0.56%), respectively; however, declined LKDC had a higher 98% risk percentile value (8.19% vs 1.02%) and were more likely to exceed a 1% ESKD risk threshold (15% vs 1%; P 0.01). The calculator captured reasons for declining donation in only 39% of LKDC; 46.9% of LKDC with Caring for Australasians with Renal Impairment contraindications were reclassified as having an acceptable (≤1%) lifetime risk and no KDIGO contraindications, primarily related to a lower pre‐donation glomerular filtration rate or controlled hypertension with obesity. Conclusion Declined LKDC had a higher 15 year but similar lifetime ESKD risk. However, the calculator successfully differentiated declined LKDC with a lifetime risk 1%. This risk calculator appears to complement but not replace clinical evaluation.
机译：摘要旨在提高全球结果的肾病（KDIGO）指南建议纳入新的风险计算器，这些风险计算器根据生活肾脏供体候选者（LKDC）的危险因素的综合剖面来定量末期肾病（ESKD）风险。我们比较了先前拒绝的eSKD风险估计与接受的LKDC，以评估该工具的预测能力和潜在影响。方法采用2007年至2015年间两名中心评估的LKDC的风险计算器计算了无捐赠的基准15年和终身ESKD风险估计。基于拟议的KDIGO和澳大利亚人的澳大利亚人的现有照顾国家指南，LKDC适用性进行了计算。结果中位数15年ESKD风险为0.14％（IQR 0.09-0.31％）在接受的LKDC（n = 89）中的0.10％（0.07-0.14％）（p <0.001）中的0.10％（0.07-0.14％）。寿命风险相似：0.39％（0.23-0.80％）分别与0.35％（0.22-0.56％）;然而，下降的LKDC风险百分率较高的98％（8.19％Vs 1.02％），更可能超过1％的ESKD风险阈值（15％Vs 1％; P <0.01）。计算器捕获了仅39％的LKDC捐款下降的原因; 46.9％的LKDC与澳大利亚人的关怀禁止禁忌禁忌症被重新分类为具有可接受的（≤1％）寿命风险，没有KDIGO禁忌症，主要与较低的润滑脂过滤速率或受控高血压有关。结论下降LKDC具有更高的15年，但类似的寿命ESKD风险。然而，计算器成功地差异化了LKDC，寿命风险＆ 1％。这种风险计算器似乎补充但不取代临床评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号