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首页> 外文期刊>Nature reviews. Neurology >Genetic and molecular epidemiology of adult diffuse glioma
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Genetic and molecular epidemiology of adult diffuse glioma

机译：成人弥漫性胶质瘤的遗传与分子流行病学

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The WHO 2007 glioma classification system (based primarily on tumour histology) resulted in considerable interobserver variability and substantial variation in patient survival within grades. Furthermore, few risk factors for glioma were known. Discoveries over the past decade have deepened our understanding of the molecular alterations underlying glioma and have led to the identification of numerous genetic risk factors. The advances in molecular characterization of glioma have reframed our understanding of its biology and led to the development of a new classification system for glioma. The WHO 2016 classification system comprises five glioma subtypes, categorized by both tumour morphology and molecular genetic information, which led to reduced misclassification and improved consistency of outcomes within glioma subtypes. To date, 25 risk loci for glioma have been identified and several rare inherited mutations that might cause glioma in some families have been discovered. This Review focuses on the two dominant trends in glioma science: the characterization of diagnostic and prognostic tumour markers and the identification of genetic and other risk factors. An overview of the many challenges still facing glioma researchers is also included.
机译：世卫组织2007年胶质瘤分类系统（主要基于肿瘤组织学）导致相当大的Interobserver变异性和患者存活率的大量变异。此外，已知有很少的胶质瘤危险因素。在过去十年中发现深化了我们对胶质瘤潜在的分子改变的理解，并导致了鉴定了许多遗传危险因素。胶质瘤的分子表征的进步已经简化了我们对生物学的理解，并导致开发新的胶质瘤分类系统。世卫组织2016分类系统包含五种胶质瘤亚型，由肿瘤形态和分子遗传信息进行分类，导致胶质瘤亚型中的错误分类和改善结果的一致性。迄今为止，已经发现了25种胶质瘤风险基因座，并且已经发现了几种可能导致某些家庭胶质瘤的罕见遗传突变。本综述侧重于胶质瘤科学的两种主导趋势：诊断和预后肿瘤标志物的表征以及遗传和其他危险因素的鉴定。还包括仍然面临胶质瘤研究人员的许多挑战的概述。

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