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首页> 外文期刊>Nature reviews. Neurology >The pro-remyelination properties of microglia in the central nervous system
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The pro-remyelination properties of microglia in the central nervous system

机译：中枢神经系统中微胶质细胞的促髓鞘化性质

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摘要

Microglia are resident macrophages of the CNS that are involved in its development, homeostasis and response to infection and damage. Microglial activation is a common feature of neurological disorders, and although in some instances this activation can be damaging, protective and regenerative functions of microglia have been revealed. The most prominent example of the regenerative functions is a role for microglia in supporting regeneration of myelin after injury, a process that is critical for axonal health and relevant to numerous disorders in which loss of myelin integrity is a prevalent feature, such as multiple sclerosis, Alzheimer disease and motor neuron disease. Although drugs that are intended to promote remyelination are entering clinical trials, the mechanisms by which remyelination is controlled and how microglia are involved are not completely understood. In this Review, we discuss work that has identified novel regulators of microglial activation - including molecular drivers, population heterogeneity and turnover - that might influence their pro-remyelination capacity. We also discuss therapeutic targeting of microglia as a potential approach to promoting remyelination.
机译：Microglia是CNS的常规巨噬细胞，涉及其发展，稳态和对感染和损害的反应。微胶质激活是神经疾病的常见特征，但在某些情况下，这种激活可能是破坏的，揭示了微胶质细胞的保护性和再生功能。再生功能的最突出的例子是小凝血性在损伤后支持髓鞘的再生的作用，这是对轴突健康的态度至关重要的过程，以及敏感霉菌丧失的疾病是一种普遍的特征，如多发性硬化，阿尔茨海默病和运动神经元疾病。虽然旨在促进重新髓鞘的药物正在进入临床试验，但控制重新激露的机制以及如何涉及微血花症的方式。在这篇综述中，我们讨论了已经确定了微胶质激活的新型调节剂的工作 - 包括分子司机，人口异质性和营业额 - 可能影响他们的亲髓鞘化能力。我们还讨论了微胶质细胞的治疗靶向作为促进重新髓鞘的潜在方法。

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