A cross-species approach to disorders affecting brain and behaviour.

Orrin Devinsky; Jordyn M Boesch; Sofia Cerda-Gonzalez; Barbara Coffey; Kathryn Davis; Daniel Friedman; Brian Hainline; Katherine Houpt; Daniel Lieberman; Pamela Perry; Harald Prüss; Martin A Samuels; Gary W Small; Holger Volk; Artur Summerfield; Charles Vite; Thomas Wisniewski; Barbara Natterson-Horowitz

首页> 外文期刊>Nature reviews. Neurology >A cross-species approach to disorders affecting brain and behaviour.

【24h】

A cross-species approach to disorders affecting brain and behaviour.

机译：一种影响大脑和行为的疾病的交叉物种方法。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.

机译：生物系统的结构和功能元素在脊椎动物上高度保守。许多神经系统和精神病病症会影响人类和动物。通过鉴定未被识别的自发性障碍的自然模型，逐步研究大脑和行为的研究可以推进我们对人类疾病的理解，从而揭示了增加脆弱性或弹性的新因素，并通过评估潜在疗法。此外，人类神经学和精神病学的诊断和治疗进展通常适用于兽医患者。然而，医生和兽医之间的临床和研究合作仍然有限，留下了这一丰富的比较信息在很大程度上是未开发的。在这里，我们审查了一系列动物物种的疼痛，认知衰退综合征，癫痫，焦虑和强迫，自身免疫和传染性脑素和错配障碍，寻找具有平移潜力的新颖洞察力。这种比较透视可以帮助产生新的假设，扩展和改善临床试验，并确定抗病性和脆弱性的自然动物模型。

著录项

来源
《Nature reviews. Neurology》 |2018年第11期|共10页
作者
Orrin Devinsky; Jordyn M Boesch; Sofia Cerda-Gonzalez; Barbara Coffey; Kathryn Davis; Daniel Friedman; Brian Hainline; Katherine Houpt; Daniel Lieberman; Pamela Perry; Harald Prüss; Martin A Samuels; Gary W Small; Holger Volk; Artur Summerfield; Charles Vite; Thomas Wisniewski; Barbara Natterson-Horowitz;
展开▼
作者单位

Department of Neurology New York University (NYU) Langone Medical Center and NYU School of;

College of Veterinary Medicine Cornell University Ithaca NY USA;

College of Veterinary Medicine Cornell University Ithaca NY USA;

Department of Child and Adolescent Psychiatry University of Miami Miller School of Medicine Miami;

Department of Neurology Perelman School of Medicine at the University of Pennsylvania;

Department of Neurology New York University (NYU) Langone Medical Center and NYU School of;

Department of Neurology New York University (NYU) Langone Medical Center and NYU School of;

College of Veterinary Medicine Cornell University Ithaca NY USA;

Department of Human Evolutionary Biology Harvard University Cambridge MA USA;

College of Veterinary Medicine Cornell University Ithaca NY USA;

Department of Neurology with Experimental Neurology Charité University Medicine Berlin Berlin;

Brigham and Women's Hospital Boston MA USA;

University of California-Los Angeles (UCLA) Brain Research Institute David Geffen School of;

Veterinary Neurology and Neurosurgery The Royal Veterinary College University of London London;

Institute of Virology and Immunology and Department of Infectious Diseases and Pathobiology;

School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA;

Department of Neurology New York University (NYU) Langone Medical Center and NYU School of;

Department of Ecology and Evolutionary Biology Division of Cardiology David Geffen School of;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词

相似文献

外文文献
中文文献
专利

1. A cross-species approach to disorders affecting brain and behaviour. [J] . Orrin Devinsky, Jordyn M Boesch, Sofia Cerda-Gonzalez, Nature reviews. Neurology . 2018,第11期

机译：一种影响大脑和行为的疾病的交叉物种方法。
2. Profiling conserved biological pathways in Autosomal Dominant Polycystic Kidney Disorder (ADPKD) to elucidate key transcriptomic alterations regulating cystogenesis: A cross-species meta-analysis approach [J] . Chatterjee Shatakshee, Verma Srikant Prasad, Pandey Priyanka Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2017,第期

机译：仿护保守的生物途径在常染色体显性多囊肾脏疾病（ADPKD）中阐明调节膀胱植物的关键转录组改变：一种跨物种Meta分析方法
3. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. [J] . van Heeringen C, Bijttebier S, Godfrin K Neuroscience and Biobehavioral Reviews . 2011,第3期

机译：自杀性大脑：与自杀行为相关的功能和结构性大脑研究的综述。
4. The Virtual Patient Simulator of Deep Brain Stimulation in the Obsessive Compulsive Disorder Based on Connectome and 7 Tesla MRI Data: The Virtual Patient Simulator of Deep Brain Stimulation in the Obsessive Compulsive Disorder [C] . Giorgio Bonmassar, Nikos Makris International Conference on Advanced Cognitive Technologies and Applications . 2014

机译：基于Constalome的强迫障碍的深脑刺激虚拟患者模拟器，7特斯拉MRI数据：强迫症深脑刺激的虚拟患者模拟器
5. An Investigation of Neurological Soft Signs as a Discriminating Factor Between Veterans With Post-Traumatic Stress Disorder, Mild Traumatic Brain Injury, and Co-occuring Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury [D] . Rothman, David Joshua. 2019

机译：创伤后应激障碍，轻度创伤性脑损伤，并发创伤后应激障碍和轻度创伤性脑损伤的退伍军人之间作为区分因素的神经软体征的调查
6. An evolutionary approach to human behaviour. [O] . D. L. Crombie 1966

机译：人类行为的进化方法。
7. Physicsmetrics, another approach to model physics systems. Application on solar panel behaviour. Advantages and complementarities with the physic’s approach. [O] . Ouzeri Leila 2021

机译：物理学识别物理学，另一种方法是模型物理系统。在太阳能电池板行为的应用。物理方法的优点和互补性。

A cross-species approach to disorders affecting brain and behaviour.

摘要

著录项

相似文献

相关主题

期刊订阅