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首页> 外文期刊>Mycotoxin Research >The first in vivo application of synthetic polymers basedon methacrylic acid as an aflatoxin sorbent in an animal model
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The first in vivo application of synthetic polymers basedon methacrylic acid as an aflatoxin sorbent in an animal model

机译：基于甲基丙烯酸的合成聚合物的第一个施用作为动物模型中的黄曲霉毒素吸附剂

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This study attempts to evaluate the potential anatoxin binder activity of a molecularly imprinted polymer (TMU95) synthesized to target the anatoxin Bi (AFBO analog molecule in comparison to a commercial toxin binder (CTB). Adsorption experiments werecarried out to assess the ability to bind to AFB[ at various pH values. The strength of binding was investigated by the chemisorption index. The isothermal analysis was used to determine the maximum adsorption capacity values. The ability of TMU95 and CTB to adsorb essential minerals was evaluated and the obtained data suggested that CTB would significantly reduce availability of them compared to TMU95. The in vivo efficacy of TMU95 as an anatoxin (AF) binder in duckling exposed to aflatoxin-contaminated feed from 4 to 18 days of age in comparison to the CTB was also assessed. TMU95 and CTB were effective in reducing the adverse effects caused by AFs on feed conversion ratio of duckling (p < 0.01), and also showed a minor reduction of injuries causedby AFs on visceral organs enlargement (p < 0.01 ). It was concluded that TMU95 could absorb AFB] in vitro efficiently and had beneficial health effects that could alleviate some of the toxic effects of AFs on growing duckling performance similar to CTB.
机译：该研究试图评估合成的分子印迹聚合物（TMU95）的潜在的抗毒素粘合剂活性以靶向anaToxin BI（与商业毒素粘合剂（CTB）相比。吸附实验正在评估结合的能力AFB [以各种pH值。通过化学吸附指数研究了结合强度。使用等温分析来确定最大吸附能力值。评估TMU95和CTB对吸附原矿物的能力，并获得了CTB的数据与TMU95相比，将显着降低它们的可用性。对于CTB的4至18天，TMU95作为鳞茎的鳞茎毒素（AF）粘合剂的体内疗效也被评为与CTB相比。TMU95和CTB有效降低AFS对Duckling饲料转化率引起的不利影响（P <0.01），并且还表现出少量减少导致AFS在内脏器官扩大（P <0.01）上。得出结论，TMU95可以有效地体外吸收AFB]，并且具有有益的健康效果，可以缓解AFS对类似CTB类似的鸭绒性能的一些毒性作用。

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