Cellular rewiring in lethal prostate cancer: the architect of drug resistance

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Cellular rewiring in lethal prostate cancer: the architect of drug resistance

机译：在致死的前列腺癌中的细胞重新灌注：耐药性的建筑师

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Management strategies used to treat prostate cancer often lead to treatment resistance, which can arise via a mechanism of cellular rewiring, whereby the tumour cell alters its signalling to escape the effects of therapy. Understanding these mechanisms could enable the development of improved and combination treatment regimens, to minimize treatment failures and improve outcomes.

机译：用于治疗前列腺癌的管理策略通常导致治疗抗性，这可能通过细胞再次灌注机制而产生，从而肿瘤细胞改变其信号以逃避治疗的影响。了解这些机制可以使改善和组合治疗方案的发展能够尽量减少治疗失败并改善结果。

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《Nature reviews. Urology》 |2020年第5期|共16页
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. 鉴别致死性与非致死性前列腺癌：PSA、PSA亚型及动力学 [J] . H Ballentine Carter 亚洲男性学杂志：英文版 . 2012,第003期
2. 积极监测是区分致死性与非致死性前列腺癌亚型的可行方法 [J] . Yoshiyuki Kakehi 亚洲男性学杂志：英文版 . 2012,第003期
3. Cellular rewiring in lethal prostate cancer: the architect of drug resistance [J] . Nature reviews. Urology . 2020,第5期

机译：在致死的前列腺癌中的细胞重新灌注：耐药性的建筑师
4. Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1 [J] . Ashley Neil, Ouaret Djamila, Bodmer Walter F. Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2019,第3期

机译：细胞极性通过多药抗性蛋白ABCB1的取向调节原代结肠直肠癌的耐药性
5. Genomics of lethal prostate cancer at diagnosis and castration resistance [J] . Joaquin Mateo, George Seed, Claudia Bertan, The journal of clinical investigation . 2020,第4期

机译：致致死前列腺癌的诊断和阉割抗性基因组学
6. Enzyme-Instructed Self-Assembly in Cellular Milieu: Bioinspired Targeting of Cancer Cells without Drug Resistance [C] . Huaimin Wang, Zhaoqianqi Feng, Jie Zhou, International Forum on Leading Edge Technologies on Crystallization Engineering and Pharmaceutics Development;Tianjin University;Tianjin Medical University . -1

机译：细胞环境中的酶指示自组装：Bioinspired对没有耐药性的癌细胞的靶向
7. Mechanism of Extracellular Matrix Induced Tumor Survival and Drug Resistance in Castration-Resistant Prostate Cancer [D] . Chaudhary, Pooja. 2019

机译：细胞外基质诱导肿瘤存活和抗阉割前列腺癌的耐药机制
8. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance [O] . Jemilat Salami, Shanique Alabi, Ryan R. Willard, 2018

机译：在前列腺癌药物耐药的细胞模型中靶向蛋白水解的嵌合体ARCC-4对雄激素受体的降解作用优于enzalutamide
9. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance [O] . Jemilat Salami, Shanique Alabi, Ryan R. Willard, 2018

机译：通过蛋白水解靶向嵌合ARCC-4的雄激素受体降解苯甲醛在前列腺癌耐药性抗药性模型中的苯甲甲酰胺
10. Innovative Strategy for Treatment of Lung Cancer: Inhalatory Codelivery of Anticancer Drugs and siRNA for Suppression of Cellular Resistance [R] . Taratula, O. 2011

机译：治疗肺癌的创新策略：抗癌药物的抑制剂和抑制细胞耐药的siRNa

Cellular rewiring in lethal prostate cancer: the architect of drug resistance

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