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首页> 外文期刊>Nature reviews. Urology >Financial toxicity associated with treatment of localized prostate cancer
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Financial toxicity associated with treatment of localized prostate cancer

机译：与局部前列腺癌治疗相关的金融毒性

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Financial toxicity is a broad term to describe the economic consequences and subjective burden resulting from a cancer diagnosis and treatment. As financial toxicity is associated with poor disease outcomes, recognition of this problem and calls for strategies to identify and support those most at risk are increasing. Men with localized prostate cancer face treatment choices including active surveillance, prostatectomy or radiotherapy. The fact that potential patient out-of-pocket costs might influence decision making has rarely been acknowledged and, overall, the risk of financial toxicity for men with localized prostate cancer remains poorly studied. This shortfall requires a work-up in the context of prostate cancer and a multidimensional framework for considering a patient's risk of financial toxicity. The major elements of this framework are direct and indirect costs, patient-specific values, expectations of possible financial burdens, and individual economic circumstances. Current data indicate that total cost patterns probably differ by treatment modality: surgery might have an increased short-term effect, whereas radiotherapy might have an increased long-term risk of financial toxicity. Specific thresholds of patient income levels or out-of-pocket costs that predict risk of financial toxicity are difficult to identify. Compared with other malignancies, prostate cancer might have a lower overall risk of financial toxicity, but persistent post-treatment urinary, bowel or sexual adverse effects are likely to increase this risk.
机译：金融毒性是一种广泛的术语来描述癌症诊断和治疗导致的经济后果和主观负担。由于金融毒性与疾病成果差，承认这一问题并要求识别和支持风险最大的战略正在增加。患有局部前列腺癌的男性面临治疗选择，包括活性监测，前列腺切除术或放射疗法。潜在的患者超出袖足费用可能影响决策的事实很少得到承认，总的来说，局部前列腺癌的男性的金融毒性风险仍然很差。这种短缺需要在前列腺癌的背景下进行处理和用于考虑患者金融毒性风险的多维框架。该框架的主要要素是直接和间接成本，患者特定的价值观，对可能的财务负担可能的预期，以及个人经济环境。目前的数据表明，总成本模式可能因治疗方式而异：手术可能具有增加的短期效果，而放射治疗可能会增加金融毒性的长期风险。特定的患者收入水平或预测金融毒性风险的折价的阈值难以识别。与其他恶性肿瘤相比，前列腺癌可能具有较低的金融毒性风险，但持续治疗后尿，肠或性不良反应可能会增加这种风险。

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