• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature reviews. Urology >Contemporary management of patients with penile cancer and lymph node metastasis
【24h】

Contemporary management of patients with penile cancer and lymph node metastasis

机译：患有阴茎癌和淋巴结转移患者的当代管理

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Penile cancer is a rare disease that causes considerable physical and psychological patient morbidity, especially at advanced stages. Patients with low-stage nodal metastasis can achieve durable survival with surgery alone, but those with extensive locoregional metastasis have overall low survival. Contemporary management strategies for lymph node involvement in penile cancer aim to minimize the morbidity associated with traditional radical inguinal lymphadenectomy through appropriate risk stratification while optimizing oncological outcomes. Modified (or superficial) inguinal lymph node dissection and dynamic sentinel lymph node biopsy are diagnostic modalities that have been recommended in patients with high-risk primary penile tumours and nonpalpable inguinal lymph nodes. In addition, advances in minimally invasive and robot-assisted lymphadenectomy techniques are being investigated in patients with penile cancer and might further decrease lymphadenectomy-related adverse effects. The management of patients with advanced disease has evolved to include multimodal treatment with systemic chemotherapy before surgical intervention and can include adjuvant chemotherapy after pelvic lymphadenectomy. The role of radiotherapy in the neoadjuvant or adjuvant setting remains largely unclear, owing to a lack of high-level evidence of possible benefits. New targeted therapies have shown efficacy in squamous cell carcinomas of other sites and might also prove effective in patients with penile cancer.
机译：阴茎癌是一种罕见的疾病，导致具有相当大的身体和心理患者的发病率，特别是在高级阶段。低阶段核糖转移的患者可以单独使用手术达到耐用的生存，但具有广泛的招生转移的人具有总体低生存率。淋巴结涉及阴茎癌的当代管理策略旨在通过适当的风险分层尽量减少与传统自由基腹膜淋巴结切除术的发病率，同时优化肿瘤学结果。改性（或浅表）腹股沟淋巴结解剖和动态哨兵淋巴结活检是诊断型号，该诊断方式推荐用于高风险的主要阴茎肿瘤和非耐受腹股沟淋巴结患者。此外，正在对阴茎癌症的患者进行微创和机器人辅助淋巴结切除术技术的进展，并且可能进一步降低淋巴结切除相关的不良反应。晚期疾病患者的管理已经进化，包括在手术干预前用全身化疗的多式化治疗，并在盆腔淋巴结切除术后包括佐剂化疗。放射疗法在新辅助或佐剂设置中的作用仍然很大程度上不清楚，由于缺乏可能的效益的高级别证据。新的靶向疗法在其他部位的鳞状细胞癌中显示出有效性，并且也可能对患有寒冷癌症的患者证明有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号