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首页> 外文期刊>Nature reviews. Urology >Personalized peptide vaccines and their relation to other therapies in urological cancer
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Personalized peptide vaccines and their relation to other therapies in urological cancer

机译：个性化肽疫苗及其与泌尿外癌症其他疗法的关系

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Immunotherapy is an important therapeutic modality for urological cancers and several immunological agents for their treatment, such as sipuleucel-T and immune checkpoint inhibitors, have been approved by the FDA. Personalized peptide vaccines (PPVs) are an immunotherapy that uses multiple cancer peptides that are selected to complement pre-existing host immunity. Vaccination with an appropriate, individualized selection of peptides, chosen from a list of candidates, induces stronger and more rapid antitumour immunity in comparison with inoculation of conventional peptide vaccines. Phase I and phase II trials have shown that PPVs are safe and effective in urological cancers. Randomized trials in patients with castration-resistant prostate cancer showed that PPVs can significantly improve progression-free survival and overall survival. However, further studies are needed to evaluate the utility of PPVs in other urological cancers, to identify those patients who will derive the greatest benefit from this approach and to optimize the protocols for combination therapies involving PPVs.
机译：免疫疗法是泌尿科癌症的重要治疗方式，并通过FDA批准了诸如Sipuleucel-T和免疫检查点抑制剂的几种免疫药物。个性化的肽疫苗（PPV）是一种免疫疗法，其使用选择的多种癌症肽来补充预先存在的宿主免疫力。与候选名单中选择的合适，个性化肽的疫苗接种，与接种常规肽疫苗相比，诱导更强和更快速的抗肿瘤免疫。 I期和II期试验表明，PPV在泌尿外癌症中是安全可有效的。抗阉割前列腺癌患者随机试验表明，PPV可显着提高无进展的存活和整体存活。然而，需要进一步的研究来评估PPV在其他泌尿外癌症中的效用，以确定那些将从这种方法中获得最大益处的那些患者，并优化涉及PPV的联合疗法的方案。

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