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首页> 外文期刊>Nature reviews. Urology >Ethnicity and ERG frequency in prostate cancer
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Ethnicity and ERG frequency in prostate cancer

机译：种族癌症中的种族和ERG频率

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摘要

Emerging observations emphasize a distinct biology of prostate cancer among men of different ethnicities and races, as demonstrated by remarkable differences in the frequency of ERG oncogenic activation, one of the most common and widely studied prostate cancer driver genes. Worldwide assessment of ERG alterations frequencies show consistent trends, with men of European ancestry having the highest rates of alteration and men of African or Asian ancestries having considerably lower alteration rates. However, data must be interpreted cautiously, owing to variations in assay platforms and specimen types, as well as ethnic and geographical classifications. Many opportunities and challenges remain in assessing cancer-associated molecular alterations at a global level, and these need to be addressed in order to realize the true potential of precision medicine for all cancer patients.
机译：新兴的观察结果强调不同种族和种族的男性前列腺癌的不同生物学，如ERG致癌活化频率的显着差异，最常见和广泛研究的前列腺癌驾驶员基因的显着差异。 全球对ERG改造频率的评估表现出一致的趋势，与欧洲祖先的人具有最高的改变和非洲或亚洲祖先的男性，具有相当较低的改变率。 然而，由于测定平台和标本类型以及种族和地理分类，因此必须谨慎地解释数据，以及种族和地理分类。 许多机会和挑战仍然在全球范围内评估癌症相关的分子改变，并且需要解决这些患者以实现所有癌症患者的精密药物的真正潜力。

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