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首页> 外文期刊>Nature reviews. Urology >Historical and contemporary perspectives on cribriform morphology in prostate cancer
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Historical and contemporary perspectives on cribriform morphology in prostate cancer

机译：历史与当代视角论前列腺癌中的Cribriform形态

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摘要

The Gleason scoring system is widely used for the grading and prognostication of prostate cancer. A Gleason pattern 4 subtype known as cribriform morphology has now been recognized as an aggressive and often lethal pattern of prostate cancer. The vast majority of published and ongoing prostate cancer studies still do not acknowledge the prognostic differences between various Gleason pattern 4 morphologies. As a result, current treatment recommendations are likely to be imprecise and not tailored towards patients who are most likely to die from the disease. Use of active surveillance for patients with Gleason score 3 + 4 prostate cancer has been suggested. However, the success of such paradigms would require cribriform morphology to be reported at the time of prostate biopsy, as patients harbouring such a pattern are poor candidates for surveillance. To date, only a limited number of studies have described the molecular alterations that occur in the cribriform morphological pattern. Further refinement of prostate cancer grading paradigms to distinguish cribriform from noncribriform Gleason pattern 4 is essential.
机译：Glason评分系统广泛用于前列腺癌的分级和预后。目前已被认为是称为Cribriform形态的胎儿图案4亚型被认为是一种激进的前列腺癌的致命和致命模式。绝大多数出版和正在进行的前列腺癌研究仍然不承认各种Gleason模式4形态之间的预后差异。因此，目前的治疗建议可能是不精确的，而不是对最有可能死于该疾病的患者量身定制。已经提出了对Gleason评分3 + 4前列腺癌的患者的主动监测。然而，这种范式的成功将需要在前列腺活检时报告克赖特型形态，因为患有这种模式的患者是监督的候选人。迄今为止，只有有限数量的研究已经描述了在CRIBRIFICLICLOGY模式中发生的分子改变。进一步改进前列腺癌分级范式以区分来自非纤胺形状Glason模式4的Cribrifice至关重要。

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