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Landmarks in prostate cancer

机译：前列腺癌中的地标

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The field of prostate cancer has been the subject of extensive research that has resulted in important discoveries and shaped our appreciation of this disease and its management. Advances in our understanding of the epidemiology, natural history, anatomy, detection, diagnosis, grading, staging, imaging, and management of prostate cancer have changed clinical practice and influenced guideline recommendations. The development of the Gleason score and subsequent modifications enabled accurate prediction of prognosis. Increased anatomical understanding and improved surgical techniques resulted in the development of nerve-sparing surgery for radical prostatectomy. The advent of active surveillance has changed the management of low-risk disease, and chemotherapy and hormonal therapy have improved the outcomes of patients with distant disease. Ongoing research and clinical trials are expected to yield more practice-changing results in the near future.
机译：前列腺癌领域一直是广泛研究的主题，导致了重要的发现和塑造了这种疾病的欣赏及其管理。 我们对新生种学，自然历史，解剖学，检测，诊断，分级，分期，成像和前列腺癌的管理的进展已经改变了临床实践和影响指导建议。 Gleason评分的发展和随后的修改使得能够精确预测预后。 增加解剖学理解和改善的手术技巧导致神经保释手术的激进前列腺切除术。 积极监测的出现已经改变了低风险疾病的管理，化疗和荷尔蒙治疗改善了患者患者的患者的结果。 持续的研究和临床试验预计将在不久的将来产生更多的实践变化结果。

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