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首页> 外文期刊>Addiction biology >Effects of cognitive bias modification training on neural signatures of alcohol approach tendencies in male alcohol-dependent patients
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Effects of cognitive bias modification training on neural signatures of alcohol approach tendencies in male alcohol-dependent patients

机译：认知偏差修饰训练对男性酒精依赖患者酒精接近倾向神经信号的影响

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摘要

Alcohol-dependent patients have been shown to faster approach than avoid alcohol stimuli on the Approach Avoidance Task (AAT). This so-called alcohol approach bias has been associated with increased brain activation in the medial prefrontal cortex and nucleus accumbens. Cognitive bias modification (CBM) has been used to retrain the approach bias with the clinically relevant effect of decreasing relapse rates one year later. The effects of CBM on neural signatures of approach/avoidance tendencies remain hitherto unknown. In a double-blind placebo-controlled design, 26 alcohol-dependent in-patients were assigned to a CBM or a placebo training group. Both groups performed the AAT for three weeks: in CBM training, patients pushed away 90 percent of alcohol cues; this rate was 50 percent in placebo training. Before and after training, patients performed the AAT offline, and in a 3T magnetic resonance imaging scanner. The relevant neuroimaging contrast for the alcohol approach bias was the difference between approaching versus avoiding alcohol cues relative to soft drink cues: [(alcohol pull>alcohol push)>(soft drink pull>soft drink push)]. Before training, both groups showed significant alcohol approach bias-related activation in the medial prefrontal cortex. After training, patients in the CBM group showed stronger reductions in medial prefrontal cortex activation compared with the placebo group. Moreover, these reductions correlated with reductions in approach bias scores in the CBM group only. This suggests that CBM affects neural mechanisms involved in the automatic alcohol approach bias, which may be important for the clinical effectiveness of CBM.
机译：与酒精依赖的患者相比，在避免进近任务（AAT）中显示出比避免饮酒刺激更快的进近方法。这种所谓的酒精疗法偏向与内侧前额叶皮层和伏隔核的大脑激活增加有关。认知偏倚修正（CBM）已用于通过在一年后降低复发率的临床相关效应来重新训练进路偏倚。迄今为止，CBM对进近/避免倾向的神经特征的影响尚不清楚。在双盲安慰剂对照设计中，将26名酒精依赖的住院患者分配到CBM或安慰剂培训组。两组均进行了三个星期的AAT：在CBM训练中，患者推开了90％的酒精提示;在安慰剂培训中，这一比例为50％。训练前后，患者在3T磁共振成像扫描仪中离线进行AAT。酒精接近偏倚的相关神经影像学对比是接近和避免酒精暗示相对于软饮料暗示之间的差异：[（酒精吸收>酒精推动）>（软饮料吸收>软饮料推动）]。训练前，两组均在前额内侧皮层显示出明显的酒精途径偏倚相关激活。训练后，与安慰剂组相比，CBM组患者的内侧前额叶皮层激活降低更明显。而且，这些减少仅与CBM组的进场偏差评分减少相关。这表明，煤层气会影响自动饮酒偏倚中涉及的神经机制，这可能对煤层气的临床有效性很重要。

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