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Blood-to-brain communication in the hypothalamus for energy intake regulation

机译:下丘脑中的血对脑通信用于能量进气调节

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摘要

The arcuate nucleus (Arc) integrates circulating hormonal and metabolic signals to control energy expenditure and intake. One of the most important routes that enables the Arc to sense circulating molecules is through the median eminence (ME), which lacks a typical blood-brain barrier. However, the mechanism by which circulating molecules reach the Arc neurons remains unclear. This review focuses on what is known to date regarding the special structure and permeability of the ME vasculature and active transport of circulating molecules from the ME to the Arc. Recent studies have demonstrated that the ME displays angiogenic behavior that is expected to provide high vascular permeability. Parenchymal diffusion of circulating molecules from the ME vasculature is size-dependent, and tanycytes actively transport circulating molecules from the ME to the Arc. Finally, we highlight structural plasticity of the Arc and ME as playing an important role in maintaining energy balance homeostasis.
机译:弧形核(ARC)集成了循环激素和代谢信号来控制能量消耗和摄入量。 最重要的路线之一,使弧形感测循环分子是通过中位数(ME),这缺乏典型的血脑屏障。 然而,循环分子到达弧神经元的机制仍然不清楚。 本综述重点介绍了关于我对ME血管系统的特殊结构和渗透率所知的迄今为止,并将循环分子从我到弧的主动运输。 最近的研究表明,我显示预期提供高血管渗透性的血管生成行为。 来自ME脉管系统的循环分子的实质扩散是尺寸依赖性的,并且Tanycytes积极地将循环分子从ME传送到弧形。 最后,我们突出了弧的结构可塑性,以及在维持能量平衡稳态中发挥重要作用。

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