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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Therapeutic potential of agmatine for CNS disorders
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Therapeutic potential of agmatine for CNS disorders

机译：用于CNS疾病的Agmatine的治疗潜力

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摘要

Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling pathways. Several studies have focused on elucidating the mechanisms underlying the neuroprotective effects of this molecule, which seems to be mediated by a reduction in oxidative damage, neuroinflammation, and proapoptotic signaling. Since these events are implicated in acute and chronic excitotoxicity-related disorders (ischemia, epilepsy, traumatic brain injury, spinal cord injury, neurodegenerative, and psychiatric disorders) as well as in nociception, agmatine has been proposed as a therapeutic strategy for the treatment of central nervous system (CNS) disorders. Agmatine also stimulates the expression of trophic factors and adult neurogenesis, contributing to its ability to induce endogenous repair mechanisms. Therefore, considering its wide range of biological effects, this review summarizes the current knowledge about its protective and regenerative properties in the CNS. (C) 2017 Elsevier Ltd. All rights reserved.
机译：Agmatine是一种调节多种神经递质和信号通路的神经调节剂。若干研究旨在阐明该分子神经保护作用的基础的机制，这似乎通过降低氧化损伤，神经炎症和促凋亡信号传导来介导。由于这些事件涉及急性和慢性兴奋毒性相关疾病（缺血，癫痫，创伤性脑损伤，脊髓损伤，神经退行性和精神病学疾病）以及毒药，因此已提出毒素作为治疗的治疗策略中枢神经系统（CNS）障碍。 Agmatine还刺激了营养因子和成人神经发生的表达，有助于其诱导内源性修复机制的能力。因此，考虑到其广泛的生物效应，本综述总结了目前关于其在CNS中保护和再生性质的知识。 （c）2017 Elsevier Ltd.保留所有权利。

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