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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Sex differences in stroke across the lifespan: The role of T lymphocytes
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Sex differences in stroke across the lifespan: The role of T lymphocytes

机译：偶尔卒中的性差异：T淋巴细胞的作用

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摘要

Stroke is a sexually dimorphic disease. Ischemic sensitivity changes throughout the lifespan and outcomes depend largely on variables like age, sex, hormonal status, inflammation, and other existing risk factors. Immune responses after stroke play a central role in how these factors interact. Although the post-stroke immune response has been extensively studied, the contribution of lymphocytes to stroke is still not well understood. T cells participate in both innate and adaptive immune responses at both acute and chronic stages of stroke. T cell responses also change at different ages and are modulated by hormones and sex chromosome complement. T cells have also been implicated in the development of hypertension, one of the most important risk factors for vascular disease. In this review, we highlight recent literature on the lymphocytic responses to stroke in the context of age and sex, with a focus on T cell response and the interaction with important stroke risk factors. (C) 2017 Elsevier Ltd. All rights reserved.
机译：中风是一种性疾病。在整个寿命和结果中的缺血性敏感性变化主要取决于年龄，性别，激素状态，炎症等现有风险因素等变量。中风后的免疫反应在这些因素互动中发挥着核心作用。虽然卒中后的免疫反应已被广泛研究，但淋巴细胞对中风的贡献仍未得到很好的理解。 T细胞参与中风的急性和慢性阶段的先天和适应性免疫应答。 T细胞应答也在不同年龄的变化，并通过激素和性染色体补充调节。 T细胞也涉及高血压的发育，血管疾病最重要的危险因素之一。在这篇综述中，我们突出了最近在年龄和性行为中淋巴细胞反应的文献，重点关注T细胞应答和与重要卒中危险因素的相互作用。 （c）2017 Elsevier Ltd.保留所有权利。

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