...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Neutrophil granulocytes in cerebral ischemia - Evolution from killers to key players
【24h】

Neutrophil granulocytes in cerebral ischemia - Evolution from killers to key players

机译：中性粒细胞粒细胞在脑缺血中 - 从杀手到关键球员的演变

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neutrophil granulocytes (or polymorphonuclear cells, PMNs) have long been considered as crude killing machines, particularly trained to attack bacterial or fungal pathogens in wounds or infected tissues. That perspective has fundamentally changed over the last decades, as PMNs have been shown to exert a livery exchange between other cells of the innate and adaptive immune system. PMNs do provide major immunomodulatory contribution during acute inflammation and subsequent clearance. Following sterile inflammation like cerebral ischemia, PMNs are among the first hematogenous cells attracted to the ischemic tissue. As inflammation is a crucial component within stroke pathophysiology, several studies regarding the role of PMNs following cerebral ischemia have been carried out. And indeed, recent research suggests a direct connection between PMNs' influx and brain damage severity. This review highlights the latest research regarding the close interconnection between PMNs and co-working cells following cerebral ischemia. We describe how PMNs are attracted to the site of injury and their tasks within the inflamed brain tissue and the periphery. We further report of new findings regarding the interaction of PMNs with resident microglia, immigrating macrophages and T cells after stroke. Finally, we discuss recent research results from experimental studies in the context with current clinical trials and point out potential new therapeutic applications that could emerge from this new knowledge on the action and interaction of PMNs following cerebral ischemia. (C) 2016 The Authors. Published by Elsevier Ltd.
机译：中性粒细胞粒细胞（或多孔核细胞，PMN）长期以来被认为是粗杀死机器，特别是训练以攻击伤口或感染组织中的细菌或真菌病原体。这一观点在过去几十年中，由于已显示PMNS在先天和自适应免疫系统的其他细胞之间发挥融合交换，因此在过去的几十年里已经改变。 PMN确实为急性炎症和随后的间隙提供了主要的免疫调节贡献。在脑缺血如脑缺血如脑缺血等之后，PMN是吸引到缺血组织的第一个血液发生细胞中。由于炎症是中风病理学生理中的关键组分，已经进行了关于PMNS在脑缺血后的作用的几项研究。事实上，最近的研究表明PMNS的流入和脑损伤严重程度之间的直接连接。本综述突出了关于脑缺血后PMNS和共同工作细胞的密切互连的最新研究。我们描述了PMNS如何吸引到受伤部位及其在发炎的脑组织和周边内的任务。我们进一步报告了关于PMN与常驻小胶质细胞的相互作用的新发现，中风后移植巨噬细胞和T细胞。最后，我们讨论了最近在目前临床试验的背景下的实验研究的研究结果，并指出了可能从这种新知识中出现的潜在新的治疗应用，这些应用可能从脑缺血后PMNS的作用和相互作用中出现。 （c）2016年作者。 elsevier有限公司出版

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号