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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins
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Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

机译：通过BCL-2家族蛋白连接线粒体动态和生命或死亡事件

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Abstract The morphology of a population of mitochondria is the result of several interacting dynamical phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these phenomena is controlled by underlying molecular machinery, and when defective can cause disease. New understanding of the relationships between form and function of mitochondria in health and disease is beginning to be unraveled on several fronts. Studies in mammals and model organisms have revealed that mitochondrial morphology, dynamics and function appear to be subject to regulation by the same proteins that regulate apoptotic cell death. One protein family that influences mitochondrial dynamics in both healthy and dying cells is the Bcl-2 protein family. Connecting mitochondrial dynamics with life-death pathway forks may arise from the intersection of Bcl-2 family proteins with the proteins and lipids that determine mitochondrial shape and function. Bcl-2 family proteins also have multifaceted influences on cells and mitochondria, including calcium handling, autophagy and energetics, as well as the subcellular localization of mitochondrial organelles to neuronal synapses. The remarkable range of physical or functional interactions by Bcl-2 family proteins is challenging to assimilate into a cohesive understanding. Most of their effects may be distinct from their direct roles in apoptotic cell death and are particularly apparent in the nervous system. Dual roles in mitochondrial dynamics and cell death extend beyond BCL-2 family proteins. In this review, we discuss many processes that govern mitochondrial structure and function in health and disease, and how Bcl-2 family proteins integrate into some of these processes. Highlights ? Multiple features of mitochondrial morphology. ? Strategies for deducing mitochondrial dynamics from morphological features. ? Eliminating neuronal mitochondria by diverse strategies. ? Bcl-2 family proteins influence mitochondrial dynamics in neurons. ? Technologies for quantifying mitochondrial dynamics.
机译：摘要线粒体群体的形态是几种相互作用的动态现象的结果，包括裂变，融合，运动，消除和生物发生。这些现象中的每一个由底层分子机械控制，并且当有缺陷会导致疾病时。新了解健康和疾病线粒体的形式和功能与功能之间的关系开始被解开在几个前面。哺乳动物和模型生物的研究表明，线粒体形态，动力学和功能似乎受到调节凋亡细胞死亡的相同蛋白质的调节。一种影响Mitococondrial动力学在健康和染色细胞中的一种蛋白质家族是Bcl-2蛋白质。与寿命死亡曲线叉的连接线粒体动态可能来自Bcl-2家族蛋白质与蛋白质和脂质的蛋白质和脂质的交叉点出现，所述蛋白质和脂质确定线粒体形状和功能。 BCL-2家族蛋白还对细胞和线粒体的影响，包括钙处理，自噬和能量学，以及线粒体细胞器对神经元突触的亚细胞定位。 Bcl-2家族蛋白质的非凡的物理或功能相互作用是挑战，以吸收到凝聚力的理解中。它们的大部分效果可能与其在凋亡细胞死亡中的直接作用不同，并且在神经系统中特别明显。线粒体动力学和细胞死亡中的双重作用延伸到Bcl-2家族蛋白之外。在本综述中，我们讨论了许多治理线粒体结构和在健康和疾病的功能的过程，以及BCL-2家族蛋白如何整合到这些过程中的一些过程中。强调 ？线粒体形态的多种特征。还从形态学特征中携带线粒体动态的策略。还通过各种策略消除神经元线粒体。还Bcl-2家族蛋白在神经元中影响线粒体动力学。还量化线粒体动力学的技术。

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