...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurobiology of learning and memory >Cannabinoid agonist administration within the cerebellar cortex impairs motor learning
【24h】

Cannabinoid agonist administration within the cerebellar cortex impairs motor learning

机译：大麻素激动剂管理在小脑皮质中损害汽车学习

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Systemic administration of cannabinoid agonists impairs cerebellum-dependent motor learning. The cannabinoid-induced impairment of motor learning has been hypothesized to be due to disruption of Purkinje cell plasticity within the cerebellar cortex. In the current study, we tested this hypothesis in rats with localized microinfusions of cannabinoid agonists and antagonists into the cerebellar cortex during eyeblink conditioning, a type of cerebellum-dependent motor learning. Infusions of the cannabinoid agonists WIN55,212-2 or ACEA directly into the eyeblink conditioning microzone of the cerebellar cortex severely impaired acquisition of eyeblink conditioning, whereas the CB1R antagonist SR141716A did not produce a significant impairment. Infusions of WIN55,212-2 outside of the eyeblink conditioning microzone did not impair motor learning, establishing anatomical specificity for the agonist effects. The motor learning impairment caused by WIN55,212-2 and ACEA was rescued by SR141716A, indicating that the learning deficit was produced through CB1Rs. The current findings demonstrate that the effects of cannabinoid receptor agonists on motor learning are localized to CB1Rs within a discrete microzone of the cerebellar cortex.
机译：大麻素激动剂的全身施用损害了小脑依赖的电机学习。大麻素诱导的电机学习损害已经假设是由于小脑皮质内的purkinje细胞可塑性破坏。在目前的研究中，我们在大鼠大麻蛋白激动剂和拮抗剂的大鼠中测试了该大鼠的假设，在拍摄的拍摄过程中，一种依赖于小脑依赖的电机学习。大麻激动剂的输注直接进入小脑皮层的拍摄微区的射击调节微区严重受损的拍摄调节，而CB1R拮抗剂SR141716A没有产生显着的损害。在眨眼调节微区外的Win55,212-2的输注没有损害电机学习，为激动剂效果建立解剖学特异性。由SR141716A救出由Win55,212-2和ACEA引起的电机学习障碍，表明通过CB1RS生产学习赤字。目前的研究结果表明，大麻素受体激动剂对电机学习的影响是在小脑皮质的离散微区内定位于CB1R。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号