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首页> 外文期刊>Neurobiology of learning and memory >Plasticity and redundancy in the integration of adult born neurons in the hippocampus
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Plasticity and redundancy in the integration of adult born neurons in the hippocampus

机译：在海马成人出生神经元整合中的可塑性和冗余

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摘要

Hippocampal neurogenesis (HN) is an extreme form of plasticity that inevitably rewires the hippocampal circuit and this rewiring was put forward as a possible mechanism for neurogenesis' behavioral effects. Here, I critically evaluate multiple lines of evidence to argue that structural plasticity induced by HN is, to a large extent, functionally redundant and thus has limited impact on behavior. The associative plasticity rules along with properties of immature neurons should only allow the survival of new neurons whose pre and postsynaptic partners have correlated activity, leading to functional redundancy. Moreover, non-redundant rewiring, even with its computational benefits, would impair meaningful communication between the hippocampus and other brain regions. This implies that associative plasticity rules constrain structural plasticity induced by neurogenesis, allowing the brain to balance plasticity and stability to maintain proper functioning. It also implies that behavioral effects of HN are mediated by other mechanisms apart from circuit rewiring.
机译：海马神经发生（HN）是一种极端的可塑性形式，不可避免地将海马电路重新丝，并作为神经发生的可能机制提出了这种重新启动的行为效应。在这里，我批判性地评估了多条证据，以争论HN诱导的结构塑性在很大程度上是功能冗余的，因此对行为产生有限的影响。联想塑性规则以及未成熟神经元的性质应仅允许新神经元的存活，其前后合作伙伴具有相关活动，导致功能冗余。此外，即使有其计算效益，非冗余重新挤出也会损害海马和其他大脑区域之间的有意义沟通。这意味着联想塑性规则限制神经发生诱导的结构可塑性，使大脑平衡可塑性和稳定性以保持正常的功能。它还意味着HN的行为效应由除电路重新安装之外的其他机制介导的。

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