...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurobiology of learning and memory >Bidirectional modulation of taste aversion extinction by insular cortex LTP and LTD
【24h】

Bidirectional modulation of taste aversion extinction by insular cortex LTP and LTD

机译：用肌肤皮层LTP和LTD双向调制味道厌灭灭绝

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The history of activity of a given neuron has been proposed to bidirectionally influence its future response to synaptic inputs. In particular, induction of synaptic plasticity expressions such as long-term potentiation (LTP) and long-term depression (LTD) modifies the performance of several behavioral tasks. Our previous studies in the insular cortex (IC), a neocortical region that has been related to acquisition and retention of conditioned taste aversion (CTA), have demonstrated that induction of LTP in the basolateral amygdaloid nucleus (Bla)-IC pathway before CTA training enhances the retention of this task. In addition, we reported that CTA training triggers a persistent impairment in the ability to induce in vivo LTP in the IC. The aim of the present study was to investigate whether LTD can be induced in the Bla-IC projection in vivo, as well as, whether the extinction of CTA is bidirectionally modified by previous synaptic plasticity induction in this pathway. Thus, rats received 900 train pulses (five 250 is pulses at 250 Hz) delivered at 1 Hz in the Bla-IC projection in order to induce LTD or 10 trains of 100 Hz/1 s with an intertrain interval of 20 s in order to induce LTP. Seven days after surgery, rats were trained in the CTA task including the extinction trials. Our results show that the Bla-IC pathway is able to express in vivo LTD in an N-Methyl-D-aspartate (NMDA) receptor-dependent manner. Induction of LTD in the Bla-IC projection previous to CTA training facilitates the extinction of this task. Conversely, LTP induction enhances CTA retention. The present results show the bidirectional modulation of CTA extinction in response to IC-LTP and LTD, providing evidence of the homeostatic adaptation of taste learning. (C) 2016 Elsevier Inc. All rights reserved.
机译：已经提出了给定神经元的活动历史，双向影响其对突触投入的未来响应。特别地，突触塑性表达的诱导如长期增强（LTP）和长期凹陷（LTD）改变了多种行为任务的性能。我们以前在蒙皮塞（IC）中的研究，一种与获取和保留条件味道厌恶（CTA）有关的新皮质区域已经证明，CTA训练前的基底外侧杏仁核（BLA）途径中LTP诱导增强这项任务的保留。此外，我们报告说，CTA培训触发了IC中诱导体内LTP的能力的持续损害。本研究的目的是研究LTD是否可以在体内的BLA-IC投影中诱导，以及CTA是否通过该途径中先前的突触塑性诱导进行双向改性。因此，在BLA-IC投影中，大鼠接收到900列车脉冲（五个250在250Hz处的脉冲），以诱导有限公司或10列300 Hz / 1s的列车，其间隔为20 s。诱导LTP。手术后七天，大鼠在CTA任务中培训，包括消失试验。我们的结果表明，BLA-IC路径能够以N-甲基-D-天冬氨酸（NMDA）受体依赖性方式在Vivo Ltd中表达。 LTD中的LTD在CTA培训之前的BLA-IC投影中促进了这项任务的灭绝。相反，LTP诱导增强了CTA保留。目前的结果表明，CTA灭绝的双向调制响应IC-LTP和LTD，提供了对味道学习的稳态适应的证据。 （c）2016年Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号