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首页> 外文期刊>Neurobiology of learning and memory >Inhibition of transcription and translation in the striatum after memory reactivation: Lack of evidence of reconsolidation
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Inhibition of transcription and translation in the striatum after memory reactivation: Lack of evidence of reconsolidation

机译：在记忆重新激活后纹状体中转录和翻译的抑制作用：缺乏重新垄断证据

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It has been found that interference with neural activity after a consolidated memory is retrieved produces an amnestic state; this has been taken has indicative of destabilization of the memory trace that would have been produced by a process of reconsolidation (allowing for maintenance of the original trace). However, a growing body of evidence shows that this is not a reliable effect, and that it is dependent upon some experimental conditions, such as the age of the memory, memory reactivation procedures, the predictability of the reactivation stimulus, and strength of training. In some instances, where post-retrieval treatments induce a retention deficit (which would be suggestive of interference with reconsolidation), memory is rescued by simple passing of time or by repeated retention tests. We now report that post-training and post retrieval inhibition of transcription and translation in dorsal striatum, a structure where both of these manipulations have not been studied, produce interference with consolidation and a transitory retention deficit, respectively. These results do not give support to the reconsolidation hypothesis and lead to the conclusion that the post-activation deficiencies are due to interference with retrieval of information. (C) 2016 Elsevier Inc. All rights reserved.
机译：已经发现，检索综合存储器后对神经活动的干扰产生了一个Amnestic状态;已经采取了这表明通过再循环过程（允许维护原始迹线）来产生的存储器迹线的稳定化。然而，越来越多的证据表明，这不是一种可靠的效果，并且它取决于一些实验条件，例如记忆的年龄，记忆重新激活程序，再激活刺激的可预测性以及训练的强度。在某些情况下，在检索后处理诱导保留缺陷（这将提示干扰重新透过的暗示）中，通过简单的时间或重复的保留测试来救出记忆。我们现在举报的是，背体纹状体的转录和翻译后的培训和后检测抑制，一种尚未研究这些操纵，分别产生干扰和暂时保持缺陷的结构。这些结果不支持重新透负假设，并导致激活后缺陷的结论是由于干扰信息的干扰。 （c）2016年Elsevier Inc.保留所有权利。

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