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首页> 外文期刊>Neurobiology of learning and memory >Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment
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Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment

机译：产前暴露对吗啡对少年大鼠空间学习和海马BDNF和长期增强的有害影响：产后跑步机运动和丰富环境的有益影响

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Highlights ? Opiates exposure prenatally results in long-lasting neurobehavioral disturbances. ? Prenatal morphine contact caused deficits in spatial memory and LTP of offspring. ? Prenatal morphine exposure also reduced hippocampal BDNF in female offspring. ? Postnatal exercise and enriched environment increased hippocampal BDNF in female offspring. ? Postnatal exercise and enriched environment improved spatial memory and LTP of offspring. Abstract Prenatal morphine exposure causes a variety of neurobehavioral alterations observed in later life. The present study investigated the effects of postnatal exercise and enriched environment (EE) on alterations in water maze learning and hippocampal long-term potentiation (LTP) and brain derived neurotrophic factor (BDNF) levels induced by exposure to morphine during prenatal period in rats. On gestation days 11–18, pregnant rats were injected twice daily with saline or morphine. Offspring were subjected to postnatal exercise and EE for 30?days and afterward, spatial learning and hippocampal LTP and BDNF levels were investigated. Prenatal morphine-exposure impaired the spatial learning and hippocampal LTP in both male and female offspring. Interestingly, postnatal exercise and EE increased performance in the water maze and improved LTP in both prenatally saline and morphine-exposed male and female rats. Prenatal morphine exposure also caused a reduction in the hippocampal BDNF levels in the female, but not male rats, and postnatal exercise and EE alleviated this deficit. Our results demonstrate that postnatal exercise and EE can improve deficits in water maze learning and hippocampal LTP and BDNF levels caused by prenatal morphine exposure.
机译：强调 ？阿片类药物暴露于持久的神经麻烦扰动。还产前吗啡接触在后代的空间记忆和LTP中造成缺陷。还产前吗啡暴露还减少了女性后代的海马BDNF。还产后运动和富集的环境在女性后代中增加海马BDNF。还产后运动和丰富的环境改善了后代的空间记忆和LTP。摘要产前式曝光导致在后期生活中观察到各种神经兽性改变。本研究调查了产后运动和富集环境（EE）对水迷宫学习和海马长期增强（LTP）和脑衍生的神经营养因子（BDNF）在大鼠产前期间诱导的脑衍生的神经营养因子（BDNF）水平的影响。在妊娠时期11-18日，每天用盐水或吗啡注射孕大鼠两次。将后代进行后期运动，并研究了30.个和之后的ee，ee，空间学习和海马LTP和BDNF水平。产前吗啡暴露在雄性和女性后代的空间学习和海马LTP受损。有趣的是，产后运动和EE在水迷宫中的性能提高，并在产量盐水和吗啡暴露的雄性大鼠中改善LTP。产前吗啡暴露也导致女性的海马BDNF水平降低，但不是雄性大鼠，并且产后运动和ee减轻了这种赤字。我们的结果表明，产后运动和EE可以改善水迷宫学习和海马LTP的缺陷，并由产前式的吗啡暴露引起的BDNF水平。

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