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首页> 外文期刊>Neurobiology of learning and memory >Distinct recruitment of the hippocampal, thalamic, and amygdalar neurons projecting to the prelimbic cortex in male and female rats during context-mediated renewal of responding to food cues
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Distinct recruitment of the hippocampal, thalamic, and amygdalar neurons projecting to the prelimbic cortex in male and female rats during context-mediated renewal of responding to food cues

机译：在上下文介导的对食品提示的续期期间，在雄性和女性大鼠中突出的海马，丘脑和Amygdalar神经元的植入植物和血肿神经元

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Persistent responding to food cues may underlie the difficulty to resist palatable foods and to maintain healthy eating habits. Renewal of responding after extinction is a model of persistent food seeking that can be used to study the underlying neural mechanisms. In context-mediated renewal, a return to the context in which the initial cue-food learning occurred induces robust responding to the cues that were extinguished elsewhere. Previous work found sex differences in context-mediated renewal and in the recruitment of the ventromedial prefrontal cortex (vmPFC) during that behavior. Males exhibited renewal of responding to food cues and had higher Fos induction in the prelimbic area (PL) of the vmPFC, while females failed to exhibit renewal of responding and had lower Fos induction in the PL. The main aim of the current study was to determine key components of the PL circuitry mediating renewal. The focus was on inputs from three areas important in appetitive associative learning and contextual processing: the amygdala, ventral hippocampal formation, and the paraventricular nucleus of the thalamus. The goal was to determine whether neurons from these areas that send direct projections to the PL (identified with a retrograde tracer) are selectively activated (Fos induction) during renewal and whether they are differently recruited in males and females. The Fos induction patterns demonstrated that the PL-projecting neurons in each of these areas were recruited in a sex-specific way that corresponded to the behavioral differences between males and females. These pathways were selectively activated in the male experimental group-the only group that showed renewal behavior. The findings suggest the pathways from the ventral hippocampal formation, paraventricular nucleus of the thalamus, and basolateral amygdala to the PL mediate renewal in males. The lack of recruitment in females suggests that under activation of these pathways may underlie their lack of renewal.
机译：对食品提示的持续反应可能使难以抵抗可口食物和保持健康的饮食习惯。灭绝后的响应是持续的食物寻求型号，可以用于研究潜在的神经机制。在上下文中期的续期中，恢复到初始提示食品学习的背景下，诱导对在其他地方熄灭的提示的强大响应。以前的工作在该行为期间发现了上下文延长和呼吸前额叶皮质（VMPFC）的招募性差异。雄性展示了对食品提示的回应，并在VMPFC的前列区（PL）中具有更高的FOS诱导，而女性未能展示续期的响应，并在PL中较低的FOS诱导。目前研究的主要目的是确定介导更新的PL电路的关键部件。重点是来自三个领域的意见，在快速联想学习和上下文处理中重要：杏仁达拉，腹侧海马形成和丘脑的椎间露细胞核。目标是确定来自这些区域的神经元是否在续期期间选择性地激活（用逆行示踪器识别）的直接突起（用逆行示踪器识别），以及它们是否被诸如雄性和女性中征收的不同。 FOS诱导模式表明，这些区域中的每一个中的PL-突出的神经元以性别特异性方式招募，所述性别的方式与男性和女性之间的行为差​​异相对应。在男性实验组中选择性地激活这些途径 - 唯一表现出更新行为的唯一组。研究结果表明，养网的腹侧海马形成，丘脑腺内细胞核和基底间杏仁核，PL中的PL介导更新。女性缺乏招募表明，在激活这些途径下可能缺乏续约。

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