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首页> 外文期刊>Neurobiology of learning and memory >Neuropeptide Y2 receptors in anteroventral BNST control remote fear memory depending on extinction training
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Neuropeptide Y2 receptors in anteroventral BNST control remote fear memory depending on extinction training

机译：Anteroventral r2的神经肽Y2受体在偏远训练中控制偏远恐惧记忆

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The anterior bed nucleus of stria terminalis (BNST) is involved in reinstatement of extinguished fear, and neuropeptide Y2 receptors influence local synaptic signaling. Therefore, we hypothesized that Y2 receptors in anteroventral BNST (BNSTav) interfere with remote fear memory and that previous fear extinction is an important variable. C57BL/6NCrl mice were fear-conditioned, and a Y2 receptor-specific agonist (NPY3-36) or antagonist (JNJ-5207787) was applied in BNSTav before fear retrieval at the following day. Remote fear memory was tested on day 16 in two groups of mice, which had (experiment 1) or had not (experiment 2) undergone extinction training after conditioning. In the group with extinction training, tests of remote fear memory revealed partial retrieval of extinction, which was prevented after blockade of Y2 receptors in BNSTav. No such effect was observed in the group with no extinction training, but stimulation of Y2 receptors in BNSTav mimicked the influence of extinction during tests of remote fear memory. Pharmacological manipulation of Y2 receptors in BNSTav before fear acquisition (experiment 3) had no effect on fear memory retrieval, extinction or remote fear memory. Furthermore, partial retrieval of extinction during tests of remote fear memory was associated with changes in number of c-Fos expressing neurons in BNSTav, which was prevented or mimicked upon Y2 blockade or stimulation in BNSTav. These results indicate that Y2 receptor manipulation in BNSTav interferes with fear memory and extinction retrieval at remote stages, likely through controlling neuronal activity in BNSTav during extinction training.
机译：StriaSivalis（BNST）的前床核伴随着脱落的恐惧恢复，神经肽Y2受体会影响局部突触信号。因此，我们假设Anteroventral BNST（BNSTAV）中的Y2受体干扰远程恐惧记忆，并且之前的恐惧灭绝是一个重要的变量。将C57BL / 6NCRL小鼠担心，并且在第二天的恐惧检索之前，在BNSTAV中施用Y2受体特异性激动剂（NPY3-36）或拮抗剂（JNJ-5207787）。在两组小鼠中，在两组小鼠中测试了遥控记忆，该小鼠（实验1）或没有（实验2）在调理后经历过消灭训练。在灭绝训练的小组中，远程恐惧记忆的测试显示出灭绝的部分检索，在BNSTAV封锁Y2受体后被预防。在该组中没有观察到这种效果，没有消灭训练，但在BNSTAV中刺激Y2受体模仿偏远恐惧记忆测试期间灭绝的影响。在恐惧习得（实验3）之前，BNSTAV在BNSTAV中的药理操纵（实验3）对恐惧记忆检索，灭绝或远程恐惧记忆没有影响。此外，在远程恐惧记忆中测试期间的消失部分检索与BNSTAV中表达神经元数量的变化有关，其在BNSTAV中防止或模仿在Y2封闭或刺激时。这些结果表明，BNSTAV中的Y2受体操纵干扰了恐惧记忆和在远程阶段的消失检索，可能通过在灭绝训练期间控制BNSTAV中的神经元活动。

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